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- Table of Contents
Facts about Immunoglobulin superfamily member 8.
May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to curb prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as crucial linkers. May also play a role on integrin- dependent morphology and motility functions.
Human | |
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Gene Name: | IGSF8 |
Uniprot: | Q969P0 |
Entrez: | 93185 |
Belongs to: |
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No superfamily |
CD316 antigen; CD316; CD81P3; CD81P3LIR-D1; EWI2; EWI-2; EWI2CD81 partner 3; Glu-Trp-Ile EWI motif-containing protein 2; IGSF8; immunoglobulin superfamily, member 8; KCT4; KCT-4; Keratinocytes-associated transmembrane protein 4; PGRL; PGRLimmunoglobulin superfamily member 8
Mass (kDA):
65.034 kDA
Human | |
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Location: | 1q23.2 |
Sequence: | 1; NC_000001.11 (160091339..160099442, complement) |
Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
Cell membrane; Single-pass membrane protein.
PMID: 11504738 by Stipp C.S., et al. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.
PMID: 12708969 by Charrin S., et al. EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells.