IFT122 Antibodies

AND IFT122 ELISA kits, IFT122 Proteins

Many biological assays use antibodies to detect IFT122, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFT122 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFT122 antibodies...

We validate the specificity of these antibodies to IFT122 by testing them on tissues known to express IFT122 positively and negatively. Browse below to find the IFT122 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IFT122 Infographic by Boster Bio

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IFT122 (NM_052989) Human Over-expression Lysate

Human

$628
Cat # LS055764
100 µg

IFT122 Overview

Facts about Intraflagellar transport protein 122 homolog.

IFT122 3D structure. Source: alphafold

Intraflagellar transport protein 122 homolog (IFT122)

Required for cilia formation through neural patterning. Acts as a negative regulator of Shh signaling.

Required to recruit TULP3 to primary cilia (By similarity). .

Gene Information

Human
Gene Name:	IFT122
Uniprot:	Q9HBG6
Entrez:	55764

Family

Belongs to:

No superfamily

Alternative Names

intraflagellar transport 122 homolog (Chlamydomonas); intraflagellar transport protein 122 homolog; SPGWD repeat-containing protein 140; WD repeat domain 10; WD repeat-containing protein 10; WDR10WDR10p; WDR140CED

Molecular Weight

Mass (kDA):
141.825 kDA

Genomic Context


Human

Location:	3q21.3-q22.1
Sequence:	3; NC_000003.12 (129440036..129520507)

Tissue Specificity

Expressed in many tissues. Predominant expression in testis and pituitary.

Subcellular Localizations

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Localizes to photoreceptor connecting cilia.

Diseases

Hereditary Diseases
Exencephaly
Jeune Thoracic Dystrophy
Cranioectodermal Dysplasia
Craniofacial Abnormalities
Retinitis Pigmentosa
Dysostoses
Short Rib-polydactyly Syndrome, Majewski Type
Dysplasia
Ciliary Motility Disorders
Familial Benign Pemphigus

Ectodermal Dysplasia
Hemorrhage
Pituitary Diseases
Curry-hall Syndrome
Ellis-van Creveld Syndrome
Type Iii Short Rib Polydactyly Syndrome

Pathways

Transport
Intraflagellar Transport
Localization
Dna Repair
Neural Tube Patterning
Limb Development

Rna Interference

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFT122

References

PMID: 11242542 by Gross C., et al. Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis.

PMID: 20889716 by Mukhopadhyay S., et al. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.