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IFNGR2 Antibodies
AND IFNGR2 ELISA kits, IFNGR2 Proteins
Many biological assays use antibodies to detect IFNGR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFNGR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFNGR2 antibodies...
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IFNGR2 Infographic by Boster Bio
All IFNGR2 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA, WB
$370
Cat # A03158-2
100 μg/vial
Cat # A03158-2
100 μg/vial
IFNGR2 Overview
Facts about Interferon gamma receptor 2.
Interferon gamma receptor 2 (IFNGR2)
Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148).
Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). .
Gene Information
| Human | |
|---|---|
| Gene Name: | IFNGR2 |
| Uniprot: | P38484 |
| Entrez: | 3460 |
Family
| Belongs to: |
|---|
| type II cytokine receptor family |
Alternative Names
AF-1; AF-1interferon-gamma receptor beta chain precursor10IFNGT1Interferon gamma receptor accessory factor 1; IFGR2; IFN-gamma R2; IFN-gamma receptor 2; IFNgammaR2; IFN-gamma-R2; IFNGR2; IFN-gR2; IFNGT1; interferon gamma receptor 2 (interferon gamma transducer 1); interferon gamma receptor 2; interferon gamma receptor accessory factor-1; interferon gamma receptor beta chain; Interferon gamma transducer 1
Molecular Weight
Mass (kDA):
37.806 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.11 |
| Sequence: | 21; NC_000021.9 (33402896..33437521) |
Tissue Specificity
Expressed in T-cells (at protein level).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm. Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling.
Diseases
- Mycobacterium Infections
- Infective Disorder
- Malignant Neoplasms
- Inflammation
- Tuberculosis
- Malignant Neoplasm Of Breast
- Immunologic Deficiency Syndromes
- Neoplasms
- Mammary Neoplasms
- Carcinoma
- Dysequilibrium Syndrome
- Hepatitis
- Malignant Neoplasm Of Prostate
Pathways
- Immune Response
- Pathogenesis
- Hypersensitivity
- Cell Growth
- Secretory Pathway
- Localization
- Secretion
- Protein Phosphorylation
- Cell Activation
- Adaptive Immune Response
- Tropism
- Inflammatory Response
- Leukocyte Activation
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFNGR2
bosterbio.com/bosterbio-gene-info-cards/IFNGR2
References
PMID: 8124716 by Soh J., et al. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor.
PMID: 8910544 by Rhee S., et al. The structure of the gene for the second chain of the human interferon gamma receptor.
2 Publications of Boster IFNGR2 Antibodies & ELISA Kits
- PubMed ID: 10.1039/C5TB00514K, Design of magnetic nanoparticles for hepatocellular carcinoma treatment using th...
- PubMed ID: , Death signal transduction induced by co-immobilized TNF-α plus IFN-γ and the d...
*More publications can be found for each product on its corresponding product page