Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5)

Interferon-induced RNA-binding protein involved in the human innate immune response. Has a flexible and broad RNA structure recognition important for RNA recognition specificity in antiviral defense.

Binds precursor and processed tRNAs in addition to poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs.