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- Table of Contents
Facts about Interferon-induced protein with tetratricopeptide repeats 3.
Exihibits an antiproliferative activity through the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 from the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation.
Human | |
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Gene Name: | IFIT3 |
Uniprot: | O14879 |
Entrez: | 3437 |
Belongs to: |
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IFIT family |
CIG-49; GARG-49; IFI60Retinoic acid-induced gene G protein; IFIT-3; IFIT-4; IFIT4IFI-60K; interferon-induced protein with tetratricopeptide repeats 3; Interferon-induced protein with tetratricopeptide repeats 4Interferon-induced 60 kDa protein; IRG2; ISG60; ISG-60; RIG-GCIG49
Mass (kDA):
55.985 kDA
Human | |
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Location: | 10q23.31 |
Sequence: | 10; NC_000010.11 (89327997..89340968) |
Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver.
Cytoplasm. Mitochondrion.
PMID: 9391139 by Zhu H., et al. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs.
PMID: 9828129 by de Veer M.J., et al. IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.