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IDO1 Antibodies
AND IDO1 ELISA kits, IDO1 Proteins
Many biological assays use antibodies to detect IDO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IDO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IDO1 antibodies...
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IDO1 Infographic by Boster Bio
All IDO1 Products
Product
Figures
Specificity
Applications
Price
Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody Picoband®
2 Citations 1 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9603
100 μg/vial
Cat # PB9603
100 μg/vial
Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody Picoband®
2 Citations 6 Q&As
Human
WB
$370
Cat # PA1611
100 μg/vial
Cat # PA1611
100 μg/vial
Mouse
ELISA, Flow Cytometry, IF, IHC, WB
$646
Cat # M01705
100ug
Cat # M01705
100ug
Human
IF, IHC, WB
$523
Cat # M01705-3
100 µl
Cat # M01705-3
100 µl
Human
IF, IHC, WB
$523
Cat # M01705-2
100 µl
Cat # M01705-2
100 µl
IDO1 Overview
Facts about Indoleamine 2,3-dioxygenase 1.
Indoleamine 2,3-dioxygenase 1 (IDO1)
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885).
Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885).
Gene Information
| Human | |
|---|---|
| Gene Name: | IDO1 |
| Uniprot: | P14902 |
| Entrez: | 3620 |
Family
| Belongs to: |
|---|
| indoleamine 2,3-dioxygenase family |
Alternative Names
3dioxygenase; EC 1.13.11.52; IDO; IDO1; IDOIDO-1; INDO; INDOindole 2,3-dioxygenase; Indoleamine 2; indoleamine 2,3-dioxygenase 1; Indoleamine 2,3-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase
Molecular Weight
Mass (kDA):
45.326 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.21 |
| Sequence: | 8; NC_000008.11 (39913891..39928790) |
Tissue Specificity
Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor- draining lymph nodes (PubMed:26155395, PubMed:25691885).
Subcellular Localizations
Cytoplasm, cytosol.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Decreased Immunologic Activity [pe]
- Carcinoma
- Autoimmunity
- Infective Disorder
- Autoimmune Diseases
- Depressive Disorder
- Autoimmune Reaction
- Malignant Tumor Of Colon
- Chronic Inflammation
Pathways
- Immune Response
- Cell Proliferation
- Pathogenesis
- Cell Activation
- T Cell Activation
- Cell Growth
- Vasodilation
- Cell Development
- Aging
- Response To Virus
- Adaptive Immune Response
- Localization
- Interleukin-10 Production
PTMs
- Acetylation
- Demethylation
- Nitration
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IDO1
bosterbio.com/bosterbio-gene-info-cards/IDO1
References
PMID: 2109605 by Dai W., et al. Molecular cloning, sequencing and expression of human interferon- gamma-inducible indoleamine 2,3-dioxygenase cDNA.
PMID: 2326172 by Tone S., et al. Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA.
2 Publications of Boster IDO1 Antibodies & ELISA Kits
- PubMed ID: 19948041, Expression of indoleamine 2, 3-dioxygenase in nasopharyngeal carcinoma impairs t...
- PubMed ID: 27418932, Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptos...
*More publications can be found for each product on its corresponding product page