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- Table of Contents
Facts about Protein-S-isoprenylcysteine O-methyltransferase.
Human | |
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Gene Name: | ICMT |
Uniprot: | O60725 |
Entrez: | 23463 |
Belongs to: |
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class VI-like SAM-binding methyltransferase superfamily |
EC 2.1.1.100; HSTE14; Isoprenylcysteine Carboxyl Methyltransferase; Isoprenylcysteine carboxylmethyltransferase; MST098; MSTP098; PCCMT; PCMT; PPMT; Prenylated Protein Carboxyl Methyltransferase; Protein-S-Isoprenylcysteine O-Methyltransferase
Mass (kDA):
31.938 kDA
Human | |
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Location: | 1p36.31 |
Sequence: | 1; NC_000001.11 (6221193..6235964, complement) |
Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 9614111 by Dai Q., et al. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum.
PMID: 10649571 by Lin X., et al. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.