Homeodomain-only protein Antibodies

Homeodomain-only protein (Hopx)

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development.

Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046).

Gene Information

Mouse
Gene Name:	Hopx
Uniprot:	Q8R1H0
Entrez:	74318

Family

Belongs to:
No superfamily

Alternative Names

CAMEO; HOD; homeodomain-only protein; HOP homeobox; HOPLAGYNECC1OB1SMAP31; Lung cancer-associated Y protein; MGC20820; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; odd homeobox 1 protein; Odd homeobox protein 1; TOTO

Molecular Weight

Mass (kDA):
8.282 kDA

Genomic Context

Mouse
Location:	5|5 C3.3
Sequence:	5;

Tissue Specificity

Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen. Throughout embryonic and postnatal development, it is expressed in the myocardium.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Invasion
• Chronic Inflammation
• Inflammation
• Colorectal Cancer
• Colitis
• Malignant Neoplasm Of Stomach
• Stomach Neoplasms
• Stenosis
• Endometrial Neoplasms
• Cardiac Hypertrophy

• Endometrial Polyp
• Neoplasm Invasiveness
• Carcinogenesis
• Eye Abnormalities
• Carcinoma
• Leukemia, Myelocytic, Acute
• Fibrosarcoma

Pathways

• Methylation
• Cell Proliferation
• Cell Cycle
• Cell Differentiation
• Dna Hypermethylation
• Stem Cell Differentiation
• Dna Methylation
• Dna Repair
• Histone Modification
• Regulation Of Gene Expression

• Regeneration
• Angiogenesis
• Wound Healing
• Pathogenesis
• Rna Interference

PTMs

• Methylation
• Demethylation

• Deacetylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Hopx

Boster Bio - Best Uses Of The HOPX Marker

These optimization tips will optimize your Boster Bio for the highest possible score.

Optimization Tips For Boster Bio

Boster Bio optimization guides are an essential part of any flow cytometry experiment. BosterBio's flow cytometry guide offers many helpful tips, troubleshooting techniques, and other useful information to help you achieve the best results. These guidelines cover everything including sample preparation, sample characterization and the proper use isotype controls and secondary antibodies. Boster Bio is also available to provide technical support, as well as blogs, disease information, and web-based digital tools.

Use the HOPX Marker

The HOPX markers are useful in brain imaging. It can detect adult stem cells in dentate gyrus. The HOPX mark is a specialized marker that can identify neurons in different brain areas. The HOPX gene is expressed in a wide variety of cell types. Here are some of the benefits that the HOPX marker can bring to brain imaging.

HOPX is expressed in ATI cells. The expression of this gene increases with age, increasing from 20% to 95% in adults. It also serves as a stem cell in the hair follicle and intestinal epithelium. It is also a tumor suppressor gene for the lung, where its regulation of cell proliferation and metastasis is important. Despite its importance in lung cancer research, little is known about the HOPX gene's role.

Hopx expression has been shown to regulate neurogenesis in the adult human hippocampus. Hopx-expressing NSCs are less likely to produce dentate gum granule neuron. Hopx may be a novel inroad to selective regulation of hippocampal neurogenesis. But despite its benefits, Hopx does not play a role in the proliferative zone of the lateral ventricle. It may have another role in regulating Notch signaling, which can be beneficial in regenerative medicine.

HOPX expression is decreased in solid tumors. Knockdown of HOPX restores tumor aggressiveness. HOPX regulates many genes. These changes will impact the function of HOPX in tumor progression. Further research will confirm the role HOPX plays in tumor progression. This gene is abundant in normal tissues, but is suppressed when it is present in cancer cells.

Recent studies have shown an association between the progression and severity of tumors when there is high HOPX. HOPX can be used in tumor imaging to help predict a patient’s future. It is important for patients to know that HOPX does not cure cancer. It can detect early symptoms and detect cancer treatment before it progresses. HOPX testing requires that the patient undergo appropriate testing.