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- Table of Contents
Facts about Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein.
Binds to ubiquilins and this interaction is required for efficient degradation of CD3D through the ERAD pathway (PubMed:18307982). .
Human | |
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Gene Name: | HERPUD1 |
Uniprot: | Q15011 |
Entrez: | 9709 |
Belongs to: |
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No superfamily |
HERPMIF1; homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-likedomain member 1 protein; homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-likedomain member 1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domainmember 1 protein; KIAA0025MMS-inducible; Methyl methanesulfonate (MMF)-inducible fragment protein 1; Mif1; SUP
Mass (kDA):
43.72 kDA
Human | |
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Location: | 16q13 |
Sequence: | 16; NC_000016.10 (56932142..56944864) |
Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 10922362 by Kokame K., et al. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress.
PMID: 11112790 by Kokame K., et al. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.