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Checkpoint protein HUS1 Antibodies
AND HUS1 ELISA kits, Checkpoint protein HUS1 Proteins
Many biological assays use antibodies to detect Checkpoint protein HUS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Checkpoint protein HUS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Checkpoint protein HUS1 antibodies...
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HUS1 Overview
Facts about Checkpoint protein HUS1.
Checkpoint protein HUS1 (HUS1)
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a significant role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.
Acts then as a sliding clamp platform on DNA for many proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) action by increasing its affinity for the 3'-OH end of this primer-template and stabilizes POLB to those websites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with dual, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.
Gene Information
| Human | |
|---|---|
| Gene Name: | HUS1 |
| Uniprot: | O60921 |
| Entrez: | 3364 |
Family
| Belongs to: |
|---|
| HUS1 family |
Alternative Names
checkpoint protein HUS1; hHUS1; HUS1 (S. pombe) checkpoint homolog; HUS1 checkpoint homolog (S. pombe); hus1+-like protein
Molecular Weight
Mass (kDA):
31.691 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p12.3 |
| Sequence: | 7; NC_000007.14 (47962980..47979619, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Cytoplasm, cytosol. In discrete nuclear foci upon DNA damage. According to PubMed:11077446, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Genotoxic Stress
- Genomic Instability
- Ataxia Telangiectasia
- Ataxia
- Telangiectasis
- Cytogenetic Abnormality
- Malignant Neoplasm Of Breast
- Carcinoma
- Physiological Stress
- Telomere Shortening
- Cell Transformation, Neoplastic
Interacting Proteins
- C4orf46
- RAD1
- RAD9A
Pathways
- Cell Cycle
- Dna Repair
- Dna Replication
- Dna Damage Checkpoint
- Cell Cycle Checkpoint
- S Phase
- Cell Cycle Arrest
- Mitosis
- Cell Death
- Localization
- Mismatch Repair
- Telomere Maintenance
- Cell Proliferation
PTMs
- Phosphorylation
- Methylation
- Reduction
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HUS1
bosterbio.com/bosterbio-gene-info-cards/HUS1
References
PMID: 9524127 by Kostrub C.F., et al. Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.
PMID: 9878245 by Dean F.B., et al. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.