HTR2B Antibodies

5-hydroxytryptamine receptor 2B (HTR2B)

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538).

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538).

Gene Information

Human
Gene Name:	HTR2B
Uniprot:	P41595
Entrez:	3357

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

5-HT(2B); 5HT2B; 5-HT2B; 5-HT-2B; 5-HT2B5-HT 2B receptor; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; HTR2B; Serotonin receptor 2B

Molecular Weight

Mass (kDA):
54.298 kDA

Genomic Context

Human
Location:	2q37.1
Sequence:	2; NC_000002.12 (231108230..231126172, complement)

Tissue Specificity

Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Diseases

• Diabetes Mellitus
• Obesity
• Carcinoma
• Neoplasms
• Gestational Diabetes
• Impaired Glucose Tolerance
• Intrahepatic Cholangiocarcinoma
• Pregnancy Complications
• Substance-related Disorders
• Tumors Of Adrenal Cortex
• Migraine With Aura
• Behavioral Tic

• Malignant Neoplasm Of Liver
• Hypokinesia
• Insulin Resistance
• Malignant Neoplasm Of Adrenal Cortex
• Common Migraine
• Malignant Neoplasms
• Nervousness

Interacting Proteins

• HTR2A
• HTR2C

Pathways

• Transport
• Cell Proliferation
• Lactation
• Parturition
• Brain Development
• Eating Behavior
• Gluconeogenesis
• Energy Homeostasis
• Regeneration
• Reverse Transcription

• Liver Regeneration
• Cognition
• Lipid Storage
• Autophagy
• Secretion

PTMs

• Phosphorylation

Research Areas

• GPCR
• Neuronal Cell Markers
• Neuroscience
• Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HTR2B

Boster Bio HTR2B Marker - Benefits and Uses

This article will discuss the benefits and uses Boster Bio's HTR2B marker. We will discuss the uses of the marker, PDZ domains and the detection method. By the end of the article, you will know whether Boster Bio's HTR2B Marker is right for your research needs. Continue reading to find out more.

Applications

The HTR2B is a marker that contains a two-nucleotide mutation located at positions +138 and +430 on the mRNA. It shares a negative regulatory function characteristic of silencer element and has a promoter region that contains a proximal as well as a distal STAT RE. It binds members in the NFI transcription factor family that exert positive regulatory effect via position –210. The proximal HTR2B promoter segment is located near the -280 STAT site and interacts with the STAT proteins to regulate HTR2B gene transcription.

Additionally, 13 STAT target regions are located in the HTR2B genes at the promoter or 5'-flanking. Among these, three DREs perfectly match the STAT consensus sequence, while the third DRE contains a three-nucleotide linker. Due to its increased affinity for STAT protein, HTR2B's 3' DRE is a potential STAT binding location.

The HTR2B is a member the 5-HT2 receptor family that functions in a variety biology processes. When ligands are bound to this receptor, they trigger a cascade in signaling by G proteins. The activity and function of downstream effectors are controlled by the signaling. HTR2B plays an important role in the normal development of the heart and in the perception of pain. This marker is only for research. It is not intended for diagnostic and therapeutic use.

Multiple STAT proteins and genes can be found in UM tumours. The HTR2B gene inducer bears multiple STAT target site sites and functionally binds with STAT family members. HTR2B is positively responsive to STAT protein inducers like IL-4, IL-6. HTR2B gene stimulater is also responsive IL-4/IL-6. These hormones mediate these responses via STAT DRE280. The positive correlation between HTR2B gene and these hormones is evident.

PDZ domains

Their Picoband catalog contains the boster bio HTR2B markers. It has been used in WB applications. It reacts with HTR2B receptors in rats and humans. It is available at 100ug/vial in WB. The end user should determine the dilutions. This marker is used in order to detect HTR2B (a cellular receptor for serotonin).

Method of detection

HTR2B is a protein that increases in expression in response to STAT-mediated interleukin signaling. T142 and T143 cell lines have elevated levels of this marker. The ratio of this marker to actin is the most commonly used method of measuring HTR2B. In the next paragraphs, we'll discuss how to detect this particular protein. This gene will be discussed in detail.

HTR2B, a member of the serotonin receptor family, includes seven subfamilies. HTR2B is described as an oncogene in some cancers, and as a tumor suppressor in others. HTR2B can still be detected using a variety of methods, but this marker can be used in order to identify patients suffering from this disease. This research may help us understand the role of this gene for the development of tumors.

Many psychiatric disorders are linked to the impulsivity genetic. It is difficult to identify genes that are responsible for impulsivity's complex origins. This genetic marker is carried by a stop codon in Finnish males. The stop codon has been found to have a significant effect on molecular function. Its association with impulsivity suggests that it may be predictive. HTR2B-containing knockout mice also displayed more impulsive behaviors that mice without it, which suggests it may play a role with psychiatric disorders.

HTR2B gene activity was detected by testing RNA and proteins from lymphoblastoid tissues. HTR2B expression was compared to several brain regions, such as the frontal cortical cortex. The HTR2B gene is highly expressed in the frontal cortex and in metastatic UM. Numerous STAT family members were implicated with HTR2B expression in these tumors.