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- Table of Contents
Facts about 5-hydroxytryptamine receptor 1D.
Ligand binding causes a conformation change that activates signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Human | |
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Gene Name: | HTR1D |
Uniprot: | P28221 |
Entrez: | 3352 |
Belongs to: |
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G-protein coupled receptor 1 family |
5HT1D; 5-HT1D; 5-HT-1D; 5-HT-1D-alpha; 5-HT1DHTR1DA; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DA; HTR1D; HTR1DA; HTRL; RDC4; RDC4,5-hydroxytryptamine receptor 1D; Serotonin receptor 1D
Mass (kDA):
41.907 kDA
Human | |
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Location: | 1p36.12 |
Sequence: | 1; NC_000001.11 (23191895..23194729, complement) |
Detected in brain neocortex and caudate nucleus (at protein level).
Cell membrane; Multi-pass membrane protein.
PMID: 1652050 by Hamblin M.W., et al. Primary structure and functional characterization of a human 5-HT1D- type serotonin receptor.
PMID: 1565658 by Weinshank R.L., et al. Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.