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- Table of Contents
Facts about Oxidoreductase HTATIP2.
May act as a redox sensor connected to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic in addition to antiangiogenic properties.
Human | |
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Gene Name: | HTATIP2 |
Uniprot: | Q9BUP3 |
Entrez: | 10553 |
Belongs to: |
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No superfamily |
30 kDa HIV-1 TAT-interacting protein; CC3oxidoreductase HTATIP2; EC 1.1.1; EC 1.1.1.-; FLJ26963; HIV-1 Tat interactive protein 2, 30 kDa; HIV-1 Tat interactive protein 2, 30kDa; HIV-1 TAT-interactive protein 2; SDR44U1; Tat-interacting protein (30kD); TIP30short chain dehydrogenase/reductase family 44U, member 1
Mass (kDA):
27.049 kDA
Human | |
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Location: | 11p15.1 |
Sequence: | 11; NC_000011.10 (20363685..20383783) |
Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.
Cytoplasm. Nucleus envelope.
PMID: 9174052 by Shtivelman E.; A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma.
PMID: 9482853 by Xiao H., et al. A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.