Heat shock protein beta-2 Antibodies

Heat shock protein beta-2 (HSPB2)

May regulate the kinase DMPK. .

Gene Information

Human
Gene Name:	HSPB2
Uniprot:	Q16082
Entrez:	3316

Family

Belongs to:
small heat shock protein (HSP20) family

Alternative Names

10 kDa chaperonin; 10 kDa heat shock protein, mitochondrial; Chaperonin 10 Homolog; Chaperonin 10; CPN10HSP10; Early-pregnancy factor; EPF; GroES; heat shock 10kD protein 1 (chaperonin 10); heat shock 10kDa protein 1 (chaperonin 10); HSP10; HSPE1

Molecular Weight

Mass (kDA):
20.233 kDA

Genomic Context

Human
Location:	11q23.1
Sequence:	11; NC_000011.10 (111912734..111914093)

Tissue Specificity

Expressed preferentially in skeletal muscle and heart but not in the lens.

Subcellular Localizations

Cytoplasm. Nucleus. Localizes to nuclear foci.

Diseases

• Cell Invasion
• Psoriasis
• Overlying Behavior
• Spastic Paraplegia, Hereditary
• Sudden Infant Death Syndrome
• Fetal Death
• Tumor Angiogenesis
• Autoimmune Reaction
• Paraplegia

• Spastic Paraplegia
• Leukodystrophy
• Hyperplasia

Interacting Proteins

• CEP19
• CRYAB
• HSPB8

Pathways

• Protein Folding
• Fertilization
• Reverse Transcription
• Cell Cycle
• Cell Death
• Zinc Ion Homeostasis
• Angiogenesis
• Wound Healing

• Exocytosis
• Sperm-egg Recognition
• Ion Homeostasis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSPB2

Best Uses Of The HSPB2 Marker

Listeria bacteria FSL M6-0635 (and Leptotrichia wadei serovar 1/2b) are two of most common bacteria found in soil samples. Both bacteria produce a HSPB2 indicator. For more information about Listeria and HSPB2 testing click here. Here are some facts.

Listeria bacterium FSL M6-0635

Boster Bio HSPB2 markers for Listeria bacterium FSL 635 can be used to detect bacteria in a variety foods. This marker can be used to distinguish Listeria bacteria FSL M6-0635 and other organisms, such as Desulfonatronum tridismutans strain MLF-1 and Leptotrichia wadei F0279.

Boster Bio HSPB2 for Listeria bacterium M6-0635 is a sensitive and specific indicator that can detect bacteria within food. The bacteria is often found in contaminated foods, such as undercooked meat. The Boster Bio HSPB2 marker can be used for Listeria bacterium M6-0635 in contaminated food.

HSPB2 Marker

The HSPB2 gene encodes a protein which is ubiquitously expressed and increases in cardiac and skeletal muscles. Overexpression of this gene increases cell survival following heat stress. HSPB2 function is not heat-inducible. Other stressors could cause HSPB2 redistribution. HSPB2 could be used to study the cardiovascular and skeletal muscular response.

The gene encoding HSPB2 may be mutated by a variety of tissues including the kidney and hepatocytes. This gene is susceptible to missense mutations. Some HSPB2 mutations can also affect expression and the dynamics of oligomerization. This research is still very early and we don't know the mechanism behind some mutations.

HSPB2 belongs to a subset that includes chaperones. It has multiple functions in maintaining cells' homeostasis. These roles are accessed through pathways that relate to protein quality control. The HSPBs play a role in the refolding, as well as the disposal, of substrate proteins. They play a role in controlling cell function, acting as chaperones, and cooperating to other chaperones.

Research into myotonia has identified the HSPB2 gene as an important component. It has been identified in two independent groups. The gene was initially called Myotonic disorder protein kinase. It is also believed to interact DMPK, a gene responsible maintaining the muscle's structure. This protein has been implicated in myotonia and is associated with deregulation of this gene.

The HSPB2 gene is also implicated in cardiac energy. In a KO mouse, HSPB2 location was increased after heat shock. This mutation causes altered cardiac activity during stress. Moreover, metabolic processes have been linked to the HSPB2 gene. Its localization in skeletal muscles was also altered after the heat shock, and an HSPB2-KO mouse model revealed increased mitochondrial activity.

For disease manifestation, a decreased level of HSPB might be sufficient. However, several studies report that HSPBs frameshift mutants are highly susceptible to protein aggregation. Protein aggregation is a hallmark for many neuronal and muscle diseases. A variety of abnormal oligomeric shapes can also overload the PQC, sequestering important elements in proteostasis.

Listeria weihenstephanensis FSL R9-0317

A CRISPR Casl3-based detection system may consist of an enzyme from the family of Caslobacteriaceae, a group that includes Listeria weihenstephanensi. This enzyme is found in a variety bacteria, including Listeria, Leptotrichia Wadei F0279 and Clostridium aminophilum.

Listeria seeligeri serovar 1/2b

The complete genome sequence from Listeria seeligeri, SLCC3954, is now freely available. It is the most compact Listeria genome. It was used to identify L. seeligeri, SLCC3954, a new strain of Listeria, and to develop diagnostic techniques. These studies have important consequences for public health.

To distinguish listeria isolates from one another, the HSPB2 gene was used. The HSPB2 genes is responsible for antimicrobial properties in many foods. It is widely used in food industry. These organisms contain the HSPB2 protein gene.

HSPB2 genes are widely used for antimicrobial uses, but there is a risk that products could be contaminated with non-pathogenic organisms. Non-pathogenic species, such as Listeria Innocua, can also make it difficult to recover L. monocytogenes. Selective enrichment can also be a source of competition between pathogenic and non-pathogenic species.

Other species Listeria seeligeri serovars were also used for this study. These included the Lachnospiraceae (FSL M6-0635) and the Opitutaceae (TAV5). The HSPB2 gene is also present in Leptotrichia wadei strain WB4 and NK4A144.