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- Table of Contents
15 Citations 5 Q&As
12 Citations 18 Q&As
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5 Citations 16 Q&As
Facts about Heat shock 70 kDa protein 1A.
The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a parasite while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state.
Human | |
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Gene Name: | HSPA1A |
Uniprot: | P0DMV8 |
Entrez: | 3303 |
Belongs to: |
---|
heat shock protein 70 family |
dnaK-type molecular chaperone HSP70-1; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127; Heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A/1B; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock-induced protein; HSP70; HSP70.1/HSP70.2; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70I; HSP72; HSPA1; HSPA1A; HSPA1B
Mass (kDA):
70.052 kDA
Human | |
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Location: | 6p21.33 |
Sequence: | 6; NC_000006.12 (31815543..31817942) |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Interested in learning more about the HSPA1A marker and Boster Bio's products? Read this article to learn more! Boster Bio has recently released the Anti-Bax Marker, a monoclonal antibody. Researchers and scientists around the world are encouraged to submit results for species, applications, or other samples to earn credit for their work. You can benefit from the program because it is available to all scientists worldwide in all disciplines.
If you want to test the effectiveness of your antibodies in detect Bax protein in human or other cells, you can try Boster Bio Anti-Bax (Bax) Monoclonal. This antibody was tested in both IHC and WB applications. It is highly compatible with all species and has a high level of reactivity towards human, mouse, and rat Bax proteins.
Cayman's Carbamylated Alpha-1 Antitrypsin K3 Polyclonal Antibody recognizes carbamylated antitrypsin at 47kDa in human specimens. This product is designed for research purposes and isn't advised for use in drug therapy.
BAX is a member of the Bcl-2 family of proteins which play an important role in the process of apoptosis. In normal conditions, BAX remains predominantly cytosolic and continuous retrotranslocation stops its accumulation in the mitochondrial outer membrane. However, during times of stress, it undergoes a change in conformation that causes it to be transferred into the mitochondrion membrane. Then, it releases cytochrome C, which induces anapoptosis.
PMID: 3931075 by Hunt C., et al. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.
PMID: 1700760 by Milner C.M., et al. Structure and expression of the three MHC-linked HSP70 genes.
*More publications can be found for each product on its corresponding product page