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Heparanase Antibodies
AND HPSE ELISA kits, Heparanase Proteins
Many biological assays use antibodies to detect Heparanase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Heparanase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Heparanase antibodies...
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HPSE Infographic by Boster Bio
All HPSE Products
Product
Figures
Specificity
Applications
Price
Anti-Heparanase 1/HPSE Antibody Picoband®
5 Citations 6 Q&As
Human, Rat
WB
$370
Cat # PB9427
100 μg/vial
Cat # PB9427
100 μg/vial
Anti-Heparanase 1 HPSE Monoclonal Antibody
2 Citations 1 Q&As
Human, Mouse, Rat
IP, WB
$370
Cat # M01313
100 μl
Cat # M01313
100 μl
HPSE Overview
Facts about Heparanase.
Heparanase (HPSE)
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and center proteoglycans. Can also cleave the linkage between a glucuronic acid component and an N-sulfo glucosamine unit carrying out a 2-O-sulfo group, but not linkages between a glucuronic acid component and a 2-O-sulfated iduronic acid moiety.
It's basically inactive at neutral pH but becomes active under acidic conditions like during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation.
Gene Information
| Human | |
|---|---|
| Gene Name: | HPSE |
| Uniprot: | Q9Y251 |
| Entrez: | 10855 |
Family
| Belongs to: |
|---|
| glycosyl hydrolase 79 family |
Alternative Names
EC 3.2; Endo-glucoronidase; HEP; Heparanase; Heparanase-1; HPA1; HPAheparanase exon 9 and 10 deletion; HPR1; HPSE; HPSE1heparanase-1; HSE1; HSE1heparanase exon10-deletion
Molecular Weight
Mass (kDA):
61.149 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q21.23 |
| Sequence: | 4; NC_000004.12 (83292461..83335153, complement) |
Tissue Specificity
Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase.
Subcellular Localizations
Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity).
Diseases
- Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasms
- Tumor Angiogenesis
- Carcinoma
- Cell Invasion
- Inflammation
- Pathologic Neovascularization
- Neoplasm Invasiveness
- Melanoma
- Malignant Paraganglionic Neoplasm
- Tissue Adhesions
Pathways
- Angiogenesis
- Cell Migration
- Cell Adhesion
- Localization
- Embryo Implantation
- Wound Healing
- Luteolysis
- Cell Proliferation
- Ovulation
- Decidualization
- Coagulation
- Tissue Remodeling
- Pathogenesis
PTMs
- Cleavage
- Phosphorylation
Research Areas
- Pancreatic Stem Cell Markers
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HPSE
bosterbio.com/bosterbio-gene-info-cards/HPSE
References
PMID: 10405343 by Kussie P.H., et al. Cloning and functional expression of a human heparanase gene.
PMID: 10446189 by Toyoshima M., et al. Human heparanase. Purification, characterization, cloning, and expression.
6 Publications of Boster Heparanase Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.carbpol.2018.10.071, Polymeric fluorescent heparin as one-step FRET substrate of human heparanase
- PubMed ID: 34112915, Noda K,Philips BJ,Snyder ME,Phillippi JA,Sullivan M,Stolz DB,Ren X,Luketich JD,S...
- PubMed ID: 24235832, Inhibition of choriocarcinoma by Fe3O4-dextran-anti-?-human chorionic gonadotrop...
- PubMed ID: 28810553, Qin Q, Xu G, Qi W, Guo M, Wang Z, Xu W, Qiao Z, Gu Y, Niu J. Exp Ther Med. 2017 ...
- PubMed ID: 24861922, Tang D, Piao Y, Zhao S, Mu X, Li S, Ma W, Song Y, Wang J, Zhao W, Zhang Q. Med O...
- PubMed ID: 23415719, Tang D, Zhang Q, Zhao S, Wang J, Lu K, Song Y, Zhao L, Kang X, Wang J, Xu S, Tia...
*More publications can be found for each product on its corresponding product page