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HPS4 Antibodies
AND HPS4 ELISA kits, HPS4 Proteins
Many biological assays use antibodies to detect HPS4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HPS4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HPS4 antibodies...
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HPS4 Overview
Facts about Hermansky-Pudlak syndrome 4 protein.
Hermansky-Pudlak syndrome 4 protein (HPS4)
Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).
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Gene Information
| Human | |
|---|---|
| Gene Name: | HPS4 |
| Uniprot: | Q9NQG7 |
| Entrez: | 89781 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Hermansky-Pudlak syndrome 4 protein
Molecular Weight
Mass (kDA):
76.919 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q12.1 |
| Sequence: | 22; NC_000022.11 (26443109..26483863, complement) |
Diseases
- Hermansky-Pudlak syndrome 4 (HPS4)
Interacting Proteins
- HPS1
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HPS4
bosterbio.com/bosterbio-gene-info-cards/HPS4
References
PMID: 11836498 by Suzuki T., et al. Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene.
PMID: 12529303 by Collins J.E., et al. Reevaluating human gene annotation: a second-generation analysis of chromosome 22.