HPGDS Antibodies

AND HPGDS ELISA kits, HPGDS Proteins

Many biological assays use antibodies to detect HPGDS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HPGDS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HPGDS antibodies...

We validate the specificity of these antibodies to HPGDS by testing them on tissues known to express HPGDS positively and negatively. Browse below to find the HPGDS antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HPGDS Infographic by Boster Bio

All HPGDS Products

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Product

Figures

Specificity

Applications

Price

Anti-PGD synthase (M115) HPGDS Antibody

Human, Mouse, Rat

$405
Cat # A05745
100ul

Human Hematopoietic Prostaglandin D Synthase/HPGDS Recombinant Protein

SDS-PAGE

$250
Cat # PROTO60760
Starting from 20ug

HPGDS (NM_014485) Human Over-expression Lysate

Human

$628
Cat # LS027306
100 µg

HPGDS Overview

Facts about Hematopoietic prostaglandin D synthase.

HPGDS 3D structure. Source: alphafold

Hematopoietic prostaglandin D synthase (HPGDS)

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide assortment of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

Gene Information

Human
Gene Name:	HPGDS
Uniprot:	O60760
Entrez:	27306

Family

Belongs to:

GST superfamily

Alternative Names

EC 2.5.1.18; EC 5.3.99.2; glutathione S-transferase sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; GST class-sigma; GSTS; GSTShematopoietic prostaglandin D2 synthase; hematopoietic prostaglandin D synthase; HPGDS; H-PGDS; PGDS; PGDSglutathione-dependent PGD synthetase; Prostaglandin-H2 D-isomerase; PTGDS2

Molecular Weight

Mass (kDA):
23.344 kDA

Genomic Context


Human

Location:	4q22.3
Sequence:	4; NC_000004.12 (94298535..94342876, complement)

Tissue Specificity

Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.

Subcellular Localizations

Cytoplasm.

Diseases

Inflammation
Neoplasms
Malignant Neoplasms
Inflammatory Response
Intestinal Neoplasms
Adenoma
Neoplasm Metastasis
Hypoxia-ischemia, Brain
Adenocarcinoma
Dystrophy
Rhinorrhea
Infarction
Polymyositis

Allergy
Muscular Dystrophy
Laryngeal Squamous Cell Carcinoma
Dyslipidemias
Congenital Muscular Dystrophy (disorder)
Metastatic Malignant Neoplasm To The Lymph Node
Spinal Cord Injuries

Interacting Proteins

ABHD17A
ARRDC3

Pathways

Localization
Inflammatory Response
Acute Inflammatory Response
Cyclooxygenase Pathway
Angiogenesis
Pathogenesis

Conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HPGDS

References

PMID: 10824118 by Kanaoka Y., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase.

PMID: 11672424 by Jowsey I.R., et al. Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH- dependent prostaglandin D2 synthases.