Homer protein homolog 1 Antibodies

Homer protein homolog 1 (HOMER1)

Binds and cross-links cytoplasmic areas of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.

May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5.

Gene Information

Human
Gene Name:	HOMER1
Uniprot:	Q86YM7
Entrez:	9456

Family

Belongs to:
Homer family

Alternative Names

homer homolog 1 (Drosophila); HOMER; HOMER1; homer-1; HOMER1A; HOMER1B; HOMER-1B; HOMER1C; SYN47; SYN47neuronal immediate early gene, 1; Ves-1

Molecular Weight

Mass (kDA):
40.277 kDA

Genomic Context

Human
Location:	5q14.1
Sequence:	5; NC_000005.10 (79372636..79514134, complement)

Subcellular Localizations

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, dendritic spine. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.

Diseases

• Pain
• Depressive Disorder
• Stress, Psychological
• Neuralgia
• Hyperalgesia
• Parkinson Disease
• Nervousness
• Peripheral Nerve Injuries
• Psychotic Disorders
• Mood Disorders
• Secondary Parkinson Disease
• Nerve Damage

• Nerve Degeneration
• Schizophrenia
• Thermal Hyperalgesia
• Alzheimer's Disease
• Anhedonia
• Cholangiocarcinoma

Interacting Proteins

• ABI3
• C19orf57
• HOMER3
• SARG
• TRAF5

Pathways

• Synaptic Transmission
• Localization
• Neurogenesis
• Sensitization
• Transport
• Aging
• Cognition
• Pathogenesis
• Secretion
• Protein Phosphorylation
• Synapse Maturation
• Electron Transport
• Regulation Of Signal Transduction

• Brain Development
• Membrane Organization
• Muscle Contraction
• Hypersensitivity
• Platelet Aggregation
• Reverse Transcription
• Membrane Depolarization

PTMs

• Phosphorylation
• Deacetylation

• Cleavage
• Acetylation

• Methylation

Research Areas

• Neuroscience
• Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HOMER1

Boster Bio - Best Uses Of The HOMER1 Marker

You might have read about the Boster Bio and are wondering how to make your experiments more efficient. If so, take a look at the Boster Bio optimization guides and suggestions. These guides will help you make informed decisions and optimize your experiments to achieve the best results. Despite the benefits of the Boster Bio, every researcher encounters some trouble in their experiments. Although there are several sources of error, proper controls will eliminate the majority of these. Boster Bio's troubleshooting guide can aid you in identifying and eliminating common errors.

Boster Bio optimization tips

The Homer1 gene is present in various tissues that include the brain, heart, and kidney. These tissues can be detected through a variety of biological assays. Antibodies to Homer1 are available in polyclonal and monoclonal forms. They react with the protein in different animal samples. Boster Bio uses mouse and rabbit for the development of these antibodies. They can associate GRM1 with intracellular calcium release and interact with the antigen 'AGAP2' to regulate the surface expression and trafficking of GRM5.

Boster Bio troubleshooting guides

It is essential to ensure that your experiment is running as it should. This is why Boster Bio has many troubleshooting guides. These guides will help you find the root of your problem, and provide you with the necessary information to resolve the issue. The guide is packed with useful tips and tricks for optimizing your research to avoid common mistakes. Troubleshooting guides can also aid in understanding how the assay operates and what variables must be managed.

Applications for HOMER1

The Homer1 gene is linked to human colorectal cancer (HCC). To determine its connection to HCC researchers tested the expression of Homer1 in two different cell lines that included the normal human colon cell line (L-02) and two other human colorectal cancer cell lines. Both HCC cell lines displayed Homer1 downregulation. The results also suggested that Homer1 could be a new biomarker in HCC.

Homer1 is a member the scaffold protein family. It is composed of two forms. It is a gene that is dysregulated and is largely associated with various cancers. We studied the expression of Homer1 in the context of hepatitis B virus-induced hepatitis C. The gene could be involved in cancer progression, as per molecular analyses of HOMER1 expression from HCC cells. This association is still being confirmed by further research.

Homer1 has been shown to regulate the activity-dependent redistribution AMPARs. The protein also regulates LTP's duration and intensity. It has many applications in neuroscience. It has been linked to the development of brain tumors. In addition to being a marker of AMPARs. HOMER1 regulates the neuronal activity-dependent alternative splicing neurexin-1.

The functional characterization of homer proteins has proved difficult, because the genes have been poorly studied in mammals. We do know that Homer is involved in the regulation of the growth and maintenance of neural networks. Drosophila's CNS is home to Homer. Its presence in the Drosophila CNS is an evidence-based proof that it is involved in locomotor activity. More research is required to understand the role played by HOMER in human diseases.

Predicted structure

To boost the efficiency of your laboratory operations For better efficiency in your laboratory, take a look at Boster's extensive collection of reagents. They include antibodies that have been validated and tested for use in IHC and WB, FC and ELISA. Boster also offers ebooks that can guide you through Flow, ChIP and ELISA. Visit the website for more details. In addition to the comprehensive list of reagents, Boster provides convenient solutions for PCR, qPCR and immunoassays.

Goals for HOMER1

The Homer1 marker is a protein that has been implicated in the development of colorectal cancer. The protein is mainly expressed in the post-synaptic densities, where it is not redistributed after an acute synaptic stimulation. Homer however, is found in peripheral tissues and has been shown to accumulate in different types of cancer cells. Shin et al. Shin et al. discovered that Homer1 stimulates lymphatic infiltration in various cancer types.

Previously there was an ICH model was developed using the femoral arterial. The A1 marker for phenotypes C3 was used to identify the astrocyte conversion. Next, Homer1 overexpression/knockdown mice were generated by adeno-associated virus infection. Homer1-kd mice were infected by selumetinib and Homer1 protein. Homer1-KO mice were also instigated to develop ICH.

Additionally Homer-related proteins are subcellularly localized, which suggests conserved functions. These proteins may have multiple functions and are therefore good targets for drugs. However, this isn't the only possible target for Homer. Insects and human cells too show a subcellular presence of Homer. Many of these proteins interact with one another, however the EVh2 domain is responsible for Homer's interaction with Shank.

In mammals, Homer proteins may play roles in synapse development and function, receptor trafficking and axon pathfinding. The Homer gene has been characterized in Drosophila. It is abundant in CNS and is associated with dendrites and the endoplasmic reticulum. It is crucial for behavior plasticity, locomotor activity and functions in locomotion.