HMGCR Antibodies

AND HMGCR ELISA kits, HMGCR Proteins

Many biological assays use antibodies to detect HMGCR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HMGCR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HMGCR antibodies...

We validate the specificity of these antibodies to HMGCR by testing them on tissues known to express HMGCR positively and negatively. Browse below to find the HMGCR antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HMGCR Infographic by Boster Bio

All HMGCR Products

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Product

Figures

Specificity

Applications

Price

Anti-HMGCR/Hmg Coa Reductase Rabbit Monoclonal Antibody

3 Q&As

Human, Mouse, Rat

IP, WB

$370
Cat # M00643
100 μl

Anti-HMGCR Antibody

Human, Mouse, Rat

IP, WB

$405
Cat # A00643-2
100ul

Anti-HMGCR Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A00643-3
100 μg/vial

HMGCR Overview

Facts about 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

HMGCR 3D structure. Source: alphafold

3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Transmembrane glycoprotein that's the rate-limiting enzyme in cholesterol biosynthesis in addition to in the biosynthesis of nonsterol isoprenoids that are important for normal cell function such as ubiquinone and geranylgeranyl proteins. .

Gene Information

Human
Gene Name:	HMGCR
Uniprot:	P04035
Entrez:	3156

Family

Belongs to:

HMG-CoA reductase family

Alternative Names

3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; EC 1.1.1; EC 1.1.1.34; HMG-CoA Reductase; HMGCR; Hydroxymethylglutaryl-CoA Reductase; LDLCQ3

Molecular Weight

Mass (kDA):
97.476 kDA

Genomic Context


Human

Location:	5q13.3
Sequence:	5; NC_000005.10 (75336334..75362116)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Cardiovascular Diseases
Malignant Neoplasms
Atherosclerosis
Hypercholesterolemia
Neoplasms
Alzheimer's Disease
Diabetes Mellitus
Heart Diseases
Inflammation
Coronary Heart Disease
Fatty Liver
Infarction
Myocardial Infarction

Liver Carcinoma
Obesity
Dyslipidemias
Hyperlipidemia
Insulin Resistance
Myopathy
Steatosis

Interacting Proteins

UBIAD1

Pathways

Cholesterol Homeostasis
Transport
Response To Statin
Pathogenesis
Secretion
Prenylation
Cell Migration
Cell Proliferation
Cell Growth
Reverse Transcription
Gluconeogenesis
Myelination
Cholesterol Efflux

Germ Cell Migration
Protein Prenylation
Lipid Homeostasis
Protein Farnesylation
Excretion
Aging
Translation

PTMs

Phosphorylation
Prenylation
Reduction
Geranylgeranylation
Cleavage
Oxidation

Methylation
Ubiquitination
Farnesylation
Glycosylation
Acetylation
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMGCR

References

PMID: 2991281 by Luskey K.L., et al. Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.

PMID: 6995544 by Brown M.S., et al. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.