HMGCL Antibodies

AND HMGCL ELISA kits, HMGCL Proteins

Many biological assays use antibodies to detect HMGCL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HMGCL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HMGCL antibodies...

We validate the specificity of these antibodies to HMGCL by testing them on tissues known to express HMGCL positively and negatively. Browse below to find the HMGCL antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HMGCL Infographic by Boster Bio

All HMGCL Products

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Product

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Specificity

Applications

Price

Anti-HMGCL Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A01886
100ul

HMGCL (NM_000191) Human Recombinant Protein

$813
Cat # PROTP35914
20 µg

Anti-HMGCL Rabbit Monoclonal Antibody

Human

IHC, WB

$370
Cat # M01886
100 μl/vial

HMGCL Overview

Facts about Hydroxymethylglutaryl-CoA lyase, mitochondrial.

HMGCL 3D structure. Source: alphafold

Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL)

Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism.

Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. .

Gene Information

Human
Gene Name:	HMGCL
Uniprot:	P35914
Entrez:	3155

Family

Belongs to:

HMG-CoA lyase family

Alternative Names

3-hydroxy-3-methylglutaryl-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-CoA lyase; EC 4.1.3.4; HLmitochondrial

Molecular Weight

Mass (kDA):
34.36 kDA

Genomic Context


Human

Location:	1p36.11
Sequence:	1; NC_000001.11 (23801877..23825459, complement)

Tissue Specificity

Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%).

Subcellular Localizations

Mitochondrion matrix. Peroxisome. Unprocessed form is peroxisomal.

Diseases

Hmg Coa Lyase Deficiency
Hypoglycemia
Inborn Errors Of Metabolism
Metabolic Acidosis
Acidosis
Comatose
Hereditary Diseases
Lethargy
Neoplasms
Inflammation
Vomiting
Neoplasm Metastasis

Mutation, Out-of-frame
Epithelioma
Tumor Progression
Malignant Neoplasm Of Breast
Mitochondrial Diseases
Hyperammonemia
Respiratory Distress

Pathways

Transport
Senescence
Reverse Transcription
Cell Proliferation
Translation
Cellular Localization
Cell Cycle
Epithelial Cell Development
Cell Development

Fatty Acid Oxidation
Localization
Excretion

PTMs

Cleavage

Oxidation

Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMGCL

References

PMID: 8440722 by Mitchell G.A., et al. 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.

PMID: 8617516 by Wang S.P., et al. 3-hydroxy-3-methylglutaryl CoA lyase (HL): mouse and human HL gene (HMGCL) cloning and detection of large gene deletions in two unrelated HL-deficient patients.