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- Table of Contents
Facts about High mobility group protein B3.
Associates with chromatin and binds DNA with a preference to non- canonical DNA structures like single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity).
Human | |
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Gene Name: | HMGB3 |
Uniprot: | O15347 |
Entrez: | 3149 |
Belongs to: |
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HMGB family |
High mobility group protein 2a; High mobility group protein 4; high mobility group protein B3; high-mobility group (nonhistone chromosomal) protein 4; high-mobility group box 3; HMG2A; HMG-2a; HMG2AHMG-4; HMG4; HMG4MGC90319; HMGB3; non-histone chromosomal protein
Mass (kDA):
22.98 kDA
Human | |
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Location: | Xq28 |
Sequence: | X; NC_000023.11 (150980507..150990775) |
Expressed predominantly in placenta.
Nucleus. Chromosome. Cytoplasm.
PMID: 9370291 by Wilke K., et al. Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a- specific 3' untranslated region.
PMID: 20598277 by Sun Y., et al. Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.