HMCES Antibodies

AND HMCES ELISA kits, HMCES Proteins

Many biological assays use antibodies to detect HMCES, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HMCES in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HMCES antibodies...

We validate the specificity of these antibodies to HMCES by testing them on tissues known to express HMCES positively and negatively. Browse below to find the HMCES antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HMCES Infographic by Boster Bio

All HMCES Products

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Figures

Specificity

Applications

Price

C3orf37 (HMCES) (NM_001006109) Human Recombinant Protein

$1249
Cat # PROTQ96FZ2
20 µg

HMCES Overview

Facts about Abasic site processing protein HMCES.

HMCES 3D structure. Source: alphafold

Abasic site processing protein HMCES (HMCES)

Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a particular reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this forecast (PubMed:23945014).

Gene Information

Human
Gene Name:	HMCES
Uniprot:	Q96FZ2
Entrez:	56941

Family

Belongs to:

SOS response-associated peptidase family

Alternative Names

chromosome 3 open reading frame 37; DC12; MGC111075

Molecular Weight

Mass (kDA):
40.575 kDA

Genomic Context


Human

Location:	3q21.3
Sequence:	3; NC_000003.12 (129278832..129306186)

Subcellular Localizations

Chromosome. Recruited to chromatin following DNA damage (PubMed:30554877). Localizes to replication forks (PubMed:30554877).

PTMs

Autocatalytic cleavage
Isopeptide bond

Phosphoprotein
Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMCES

References

PMID: 23945014 by Aravind L., et al. Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems.

PMID: 30554877 by Mohni K.N., et al. HMCES maintains genome integrity by shielding abasic sites in single- strand DNA.