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Porphobilinogen deaminase Antibodies
AND HMBS ELISA kits, Porphobilinogen deaminase Proteins
Many biological assays use antibodies to detect Porphobilinogen deaminase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Porphobilinogen deaminase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Porphobilinogen deaminase antibodies...
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HMBS Infographic by Boster Bio
All HMBS Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M01506-1
100 µl
Cat # M01506-1
100 µl
HMBS Overview
Facts about Porphobilinogen deaminase.
Porphobilinogen deaminase (HMBS)
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in many discrete steps. .
Gene Information
| Human | |
|---|---|
| Gene Name: | HMBS |
| Uniprot: | P08397 |
| Entrez: | 3145 |
Family
| Belongs to: |
|---|
| HMBS family |
Alternative Names
hydroxymethylbilane synthasePre-uroporphyrinogen synthase; PBGDPBG-D; PORC; porphobilinogen deaminase; porphyria, acute; Chester type; UPSEC 2.5.1.61; uroporphyrinogen I synthase; uroporphyrinogen I synthetase
Molecular Weight
Mass (kDA):
39.33 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (119084864..119093549) |
Tissue Specificity
Isoform 1 is ubiquitously expressed. Isoform 2 is found only in erythroid cells.
Subcellular Localizations
Cytoplasm.
Diseases
- Acute Intermittent Porphyria
- Disorders Of Porphyrin Metabolism
- Acute Interstitial Pneumonia
- Neoplasms
- Malignant Neoplasms
- Porphyrias, Hepatic
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Hypokinesia
- Neoplasm Metastasis
- Porphyria Cutanea Tarda
- Hereditary Coproporphyria
Pathways
- Reverse Transcription
- Pathogenesis
- Localization
- Osteoblast Differentiation
- Aging
- Cytokine Secretion
- Immune Response
- Regulation Of Gene Expression
- Chromosome Segregation
- Cytokine Production
PTMs
- Reduction
Research Areas
- Diabetes Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HMBS
bosterbio.com/bosterbio-gene-info-cards/HMBS
References
PMID: 2875434 by Raich N., et al. Molecular cloning and complete primary sequence of human erythrocyte porphobilinogen deaminase.
PMID: 3816774 by Grandchamp B., et al. Tissue-specific expression of porphobilinogen deaminase. Two isoenzymes from a single gene.