HM13 Antibodies

AND HM13 ELISA kits, HM13 Proteins

Many biological assays use antibodies to detect HM13, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HM13 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HM13 antibodies...

We validate the specificity of these antibodies to HM13 by testing them on tissues known to express HM13 positively and negatively. Browse below to find the HM13 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HM13 Infographic by Boster Bio

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Signal Peptide Peptidase (HM13) (NM_030789) Human Over-expression Lysate

Human

$628
Cat # LS081502
100 µg

HM13 Overview

Facts about Minor histocompatibility antigen H13.

HM13 3D structure. Source: alphafold

Minor histocompatibility antigen H13 (HM13)

Catalyzes intramembrane proteolysis of a signal peptides after they have been cleaved from a preprotein, leading to the discharge of the fragment from the ER membrane to the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810).

Might be necessary for the elimination of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of this integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365).

Gene Information

Human
Gene Name:	HM13
Uniprot:	Q8TCT9
Entrez:	81502

Family

Belongs to:

peptidase A22B family

Alternative Names

dJ324O17.1; EC 3.4.23.-; H13hIMP1; histocompatibility (minor) 13; IMP-1; IMP1MSTP086; Intramembrane protease 1; minor histocompatibility antigen 13; minor histocompatibility antigen H13; Presenilin-like protein 3; PSENL3; PSL3IMPAS; signal peptide peptidase beta; Signal peptide peptidase; SPPIMPAS-1

Molecular Weight

Mass (kDA):
41.488 kDA

Genomic Context


Human

Location:	20q11.21
Sequence:	20; NC_000020.11 (31514410..31569567)

Tissue Specificity

Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.