HLA-G Antibodies

AND HLA-G ELISA kits, HLA-G Proteins

Many biological assays use antibodies to detect HLA-G, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HLA-G in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HLA-G antibodies...

We validate the specificity of these antibodies to HLA-G by testing them on tissues known to express HLA-G positively and negatively. Browse below to find the HLA-G antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HLA-G Infographic by Boster Bio

All HLA-G Products

Product

Figures

Specificity

Applications

Price

Anti-HLA G Rabbit Monoclonal Antibody

4 Q&As

Human

$370
Cat # M01235
100 μl

Anti-HLA-G Purified Azide Free Monoclonal Antibody

Human

ELISA, Flow Cytometry, IP, IHC-F, ICC

$336
Cat # M01235-2
0.1 mg

Anti-HLA-G Antibody

Human, Mouse, Rat

$405
Cat # A01235
100ul

Human HLA-G Recombinant Protein

SDS-PAGE

$250
Cat # PROTP17693
Starting from 4ug

HLAG (HLA-G) (NM_002127) Human Over-expression Lysate

Human

$628
Cat # LS003135
100 µg

HLA-G Overview

Facts about HLA class I histocompatibility antigen, alpha chain G.

HLA-G 3D structure. Source: alphafold

HLA class I histocompatibility antigen, alpha chain G (HLA-G)

Isoform 1: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal port (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complicated with B2M/beta-2 microglobulin binds a restricted repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247).

Peptide-bound HLA-G-B2M complex functions as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development whilst preserving maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it activates NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799).

Gene Information

Human
Gene Name:	HLA-G
Uniprot:	P17693
Entrez:	3135

Family

Belongs to:

MHC class I family

Alternative Names

b2 microglobulin; HLA class I histocompatibility antigen, alpha chain G; HLA class I molecule; HLA G antigen; HLA G; HLA-6.0; HLA-G histocompatibility antigen, class I, G; HLAG; HLA-G; major histocompatibility complex, class I, G; MHC Class I Antigen G; MHC-G

Molecular Weight

Mass (kDA):
38.224 kDA

Genomic Context


Human

Location:	6p22.1
Sequence:	6; NC_000006.12 (29826979..29831130)

Tissue Specificity

Expressed in extravillous trophoblasts and cytotrophoblasts (PubMed:26460007, PubMed:16210391, PubMed:7589701). Expressed in adult eye (PubMed:1570318). Expressed in immune cell subsets including monocytes, myeloid and plasmacytoid dendritic cells and regulatory T cells (Tr1)(at protein level) (PubMed:20448110). Secreted by follicular dendritic cell and follicular helper T cells (PubMed:24453251). Isoform 5: Detected in physiological fluids including amniotic fluid and serum (PubMed:11137219). Isoform 7: Expressed in placenta, amniotic membrane, skin cord blood and peripheral blood mononuclear cells (PubMed:11137219).

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Early endosome membrane.; [Soluble HLA class I histocompatibility antigen, alpha chain G]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Secreted. Early endosome.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; Cell projection, filopodium membrane. HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the ma

Diseases

Neoplasms
Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Carcinoma
Pre-eclampsia
Choriocarcinoma
Cell Invasion
Melanoma
Autoimmune Reaction
Decreased Immunologic Activity [pe]
Inflammation
Leukemia

Pregnancy Complications
Autoimmune Diseases
Infective Disorder
Dysequilibrium Syndrome
Tumor Escape
Virus Diseases

Interacting Proteins

LILRB1
LILRB2

Pathways

Immune Response
Secretion
Pathogenesis
Cytolysis
Fertilization
Cytokine Production
Cell Proliferation
Translation
Localization
Transport
Cell Activation
Cytokine Secretion
T Cell Proliferation

Methylation
Embryo Development
Angiogenesis
Dna Methylation
Reverse Transcription
T Cell Activation
Cell Differentiation

PTMs

Cleavage
Methylation
Phosphorylation
Demethylation
Biotinylation
Dephosphorylation

Nitration
Glycosylation
Deacetylation
Acetylation
Reduction
Gpi Anchoring

Research Areas

Adaptive Immunity
Cell Biology
Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HLA-G

References

PMID: 2336406 by Shukla H., et al. The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression.

PMID: 3480534 by Geraghty D.E., et al. A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.