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- Table of Contents
Facts about HLA class II histocompatibility antigen, DR beta 4 chain.
The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
Human | |
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Gene Name: | HLA-DRB4 |
Uniprot: | P13762 |
Entrez: | 3126 |
Belongs to: |
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MHC class II family |
class II histocompatibility antigen HLA DR alpha, beta1-0307; DR12; DR-12; DR13; DR-13; DR14; DR-14; DR4; DR-4; DRB1 transplantation antigen; DRB4; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DRB1-12 beta chain; HLA class II histocompatibility antigen, DRB1-4 beta chain; HLA-DR4B; human leucocyte antigen DRB4; leucocyte antigen DRB1; leukocyte antigen; major histocompatibility complex, class II, DR beta 1; major histocompatibility complex, class II, DR beta 4; MHC class I antigen DRB1*12; MHC class I antigen DRB1*4; MHC class II antigen DR
Mass (kDA):
29.941 kDA
Human | |
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Location: | 6p21.3 |
Sequence: | 6; NT_167246.2 (3840427..3855395, complement) |
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
PMID: 3110774 by Young J.A.T., et al. Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.
PMID: 11972878 by De Pablo R., et al. Specific amplification of the HLA-DRB4 gene from c-DNA. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033.