HJURP Antibodies

AND HJURP ELISA kits, HJURP Proteins

Many biological assays use antibodies to detect HJURP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HJURP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HJURP antibodies...

We validate the specificity of these antibodies to HJURP by testing them on tissues known to express HJURP positively and negatively. Browse below to find the HJURP antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HJURP Infographic by Boster Bio

All HJURP Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-HJURP Antibody

Human

ELISA, WB

$380
Cat # A03856
100ul

Anti-Hjurp Antibody Picoband®

Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A03856-1
100 μg/vial

HJURP (NM_018410) Human Over-expression Lysate

Human

$628
Cat # LS055355
100 µg

HJURP Overview

Facts about Holliday junction recognition protein.

HJURP 3D structure. Source: alphafold

Holliday junction recognition protein (HJURP)

Centromeric protein which plays a central role in the incorporation and maintenance of histone H3-like version CENPA in centromeres. Acts as a specific chaperone for CENPA and is necessary for the incorporation of newly synthesized CENPA molecules to nucleosomes at replicated centromeres.

Prevents CENPA-H4 tetramerization and prevents premature DNA binding from the CENPA-H4 tetramer. Directly binds Holliday junctions.

Gene Information

Human
Gene Name:	HJURP
Uniprot:	Q8NCD3
Entrez:	55355

Family

Belongs to:

No superfamily

Alternative Names

FAKTS14-3-3-associated AKT substrate; fetal liver expressing gene 1; Fetal liver-expressing gene 1 protein; FLEG1; hFLEG1; Holliday junction recognition protein; Up-regulated in lung cancer 9; URLC9DKFZp762E1312

Molecular Weight

Mass (kDA):
83.539 kDA

Genomic Context


Human

Location:	2q37.1
Sequence:	2; NC_000002.12 (233836701..233854566, complement)

Tissue Specificity

According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.

Subcellular Localizations

Nucleus, nucleolus. Chromosome, centromere. Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Instabilities, Chromosomal
Recurrent Colorectal Carcinoma
Multiple Malignancy
Ataxia
Genomic Instability
Glioma
Malignant Paraganglionic Neoplasm
Malignant Glioma

Brain Neoplasms
Malignant Neoplasm Of Lung
Carcinogenesis
Ataxia Telangiectasia
Telangiectasis
Malignant Neoplasm Of Testis
Colorectal Cancer

Interacting Proteins

CENPA

Pathways

Cell Cycle
Chromosome Segregation
Chromatin Assembly
Localization
Mitosis
Methylation
Cell Division
Nucleosome Assembly
S Phase
Kinetochore Assembly
Interphase
G1 Phase
Dna Repair

Metaphase
Anaphase
Senescence
Dna Replication
Reverse Transcription
Cell Growth
Secretion

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HJURP

References

PMID: 17823411 by Kato T., et al. Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.

PMID: 16622419 by Foltz D.R., et al. The human CENP-A centromeric nucleosome-associated complex.