HIF1AN Antibodies

AND HIF1AN ELISA kits, HIF1AN Proteins

Many biological assays use antibodies to detect HIF1AN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HIF1AN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HIF1AN antibodies...

We validate the specificity of these antibodies to HIF1AN by testing them on tissues known to express HIF1AN positively and negatively. Browse below to find the HIF1AN antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HIF1AN Infographic by Boster Bio

All HIF1AN Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-HIF1AN Antibody

Human, Mouse, Rat

IP, IF, ICC, WB

$405
Cat # A02116
100ul

Anti-HIF1AN Antibody

Human

Flow Cytometry, IHC, ICC, WB

$405
Cat # A02116-1
100ul

Human FIH-1/HIF-1AN Recombinant Protein

SDS-PAGE

$234
Cat # PROTQ9NWT6
Starting from 20ug

Anti-HIF1AN Antibody (C-term)

Human

IF, WB

$299
Cat # M02116-1
50 µl

Anti-HIF1AN Rabbit Monoclonal Antibody

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M02116-2
100 μl/vial

HIF1AN (NM_017902) Human Over-expression Lysate

Human

$628
Cat # LS055662
100 µg

HIF1AN Overview

Facts about Hypoxia-inducible factor 1-alpha inhibitor.

HIF1AN 3D structure. Source: alphafold

Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN)

Hydroxylates HIF-1 alpha 'Asn-803' from the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators such as Cbp/p300- interacting transactivator.

Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.

Gene Information

Human
Gene Name:	HIF1AN
Uniprot:	Q9NWT6
Entrez:	55662

Family

Belongs to:

No superfamily

Alternative Names

DKFZp762F1811; EC 1.14.11.16; factor inhibiting HIF1; Factor inhibiting HIF-1; FIH1; FIH-1; FIH1FIH-1; FLJ20615; FLJ22027; HIF1AN; HIF-1AN; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; Hypoxia-inducible factor asparagine hydroxylase; Peptide-aspartate beta-dioxygenase

Molecular Weight

Mass (kDA):
40.285 kDA

Genomic Context


Human

Location:	10q24.31
Sequence:	10; NC_000010.11 (100535921..100559998)

Subcellular Localizations

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

Diseases

Hypoxia
Neoplasms
Malignant Neoplasms
Anoxia
Tumor Angiogenesis
Carcinoma
Von Hippel-lindau Syndrome
Adenocarcinoma
Kidney Neoplasm
Respiratory Distress Syndrome, Adult
Pathologic Neovascularization
Renal Cell Carcinoma

Mammary Neoplasms
Inflammation
Malignant Neoplasm Of Breast
Liver Neoplasms
Lung Neoplasms
Metastatic Malignant Neoplasm To The Lymph Node
Liver Carcinoma

Interacting Proteins

ANKRD49
APBA3
ASB9
FEM1B
HIF1A

ILK
NFKB1
NFKBIA
OTUB1
PSMD10

RIPK4
TNKS
TNKS2
UACA

Pathways

Angiogenesis
Glycolysis
Localization
Oxygen Homeostasis
Cell Proliferation
Response To Hypoxia
Methylation
Cell Growth
Cellular Response To Hypoxia
Transport
Cell Migration
Dna Hypermethylation
Tube Formation

Immune Response
Proteolysis
Neurogenesis
Oxidative Phosphorylation
Keratinocyte Differentiation
Vasculogenesis
Regulation Of Histone Methylation

PTMs

Hydroxylation
Ubiquitination

Phosphorylation
Methylation

Acetylation

Research Areas

Angiogenesis
Cancer
Chromatin Research
Hypoxia
Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HIF1AN

References

PMID: 11641274 by Mahon P.C., et al. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.

PMID: 12080085 by Lando D., et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.