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Protein HEXIM1 Antibodies
AND HEXIM1 ELISA kits, Protein HEXIM1 Proteins
Many biological assays use antibodies to detect Protein HEXIM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein HEXIM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein HEXIM1 antibodies...
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HEXIM1 Overview
Facts about Protein HEXIM1.
Protein HEXIM1 (HEXIM1)
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In collaboration with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869).
May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Gene Information
| Human | |
|---|---|
| Gene Name: | HEXIM1 |
| Uniprot: | O94992 |
| Entrez: | 10614 |
Family
| Belongs to: |
|---|
| HEXIM family |
Alternative Names
Cardiac lineage protein 1; CLP1; CLP-1; CLP1hexamethylene-bis-acetamide-inducible transcript 1; EDG1HMBA-inducible; Estrogen down-regulated gene 1 protein; hexamethylene bis-acetamide inducible 1; Hexamethylene bis-acetamide-inducible protein 1; hexamthylene bis-acetamide inducible 1; Hexim 1; HEXIM1; HIS1; HIS1FLJ13562; HMBA-inducible; MAQ1; MAQ1hexamethylene bisacetamide-inducible protein; menage a quatre 1; Menage a quatre protein 1; protein HEXIM1
Molecular Weight
Mass (kDA):
40.623 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (45148475..45152099) |
Tissue Specificity
Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
Subcellular Localizations
Nucleus. Cytoplasm. Binds alpha-importin and is mostly nuclear (PubMed:16362050).
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Hypertrophy
- Malignant Neoplasms
- Neoplasms
- Cardiac Hypertrophy
- Leukemia
- Malignant Neoplasm Of Breast
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Acquired Immunodeficiency Syndrome
Interacting Proteins
- CCNT1
- CDK9
- HEXIM2
- LARP7
- TERF2
Pathways
- Localization
- Cell Growth
- Viral Transcription
- Cell Cycle
- Cell Differentiation
- Pathogenesis
- Proteolysis
- Cell Cycle Arrest
- Nuclear Import
- Cell Proliferation
- Regeneration
- Cell Adhesion
- Transport
PTMs
- Phosphorylation
- Dephosphorylation
- Ubiquitination
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HEXIM1
bosterbio.com/bosterbio-gene-info-cards/HEXIM1
References
PMID: 12941847 by Wittmann B.M., et al. Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors.
PMID: 12581153 by Ouchida R., et al. Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells.