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- Table of Contents
Facts about Lymphoid-specific helicase.
Needed for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation.
Human | |
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Gene Name: | HELLS |
Uniprot: | Q9NRZ9 |
Entrez: | 3070 |
Belongs to: |
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SNF2/RAD54 helicase family |
EC 3.6.1; EC 3.6.4.-; helicase, lymphoid-specific; LSHSWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin; Nbla10143; PASGFLJ10339; Proliferation-associated SNF2-like protein; SMARCA6lymphoid-specific helicase; subfamily A, member 6; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 6
Mass (kDA):
97.074 kDA
Human | |
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Location: | 10q23.33 |
Sequence: | 10; NC_000010.11 (94545767..94613905) |
Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
Nucleus. Closely associated with pericentric heterochromatin.
PMID: 10910076 by Lee D.W., et al. Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia.
PMID: 15305370 by Yano M., et al. Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer.