Histone deacetylase 7 (HDAC7)

Responsible for the deacetylation of lysine residues on the N-terminal portion of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays a significant role in transcriptional regulation, cell cycle progression and developmental events.

Involved in muscle maturation by repressing transcription of myocyte enhancer factors like MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles to the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity).