Orexin Antibodies

AND HCRT ELISA kits, Orexin Proteins

Many biological assays use antibodies to detect Orexin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Orexin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Orexin antibodies...

We validate the specificity of these antibodies to Orexin by testing them on tissues known to express HCRT positively and negatively. Browse below to find the HCRT antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HCRT Infographic by Boster Bio

All HCRT Products

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Product

Figures

Specificity

Applications

Price

Anti-OREX HCRT Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A01633
100ul

Orexin (HCRT) (NM_001524) Human Over-expression Lysate

Human

$628
Cat # LS003060
100 µg

Anti-HCRT Antibody

Mouse, Rat

IF, IHC

$370
Cat # A01633-1
100 µg/vial

HCRT Overview

Facts about Orexin.

HCRT 3D structure. Source: alphafold

Orexin (HCRT)

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the intricate behavioral and physiological responses of these complementary homeostatic functions. A wider role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also proposed.

Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. .

Gene Information

Human
Gene Name:	HCRT
Uniprot:	O43612
Entrez:	3060

Family

Belongs to:

orexin family

Alternative Names

Hcrt 2; HCRT; Hcrt2; Hypocretin (orexin) neuropeptide precursor; Hypocretin 2; Hypocretin B; Hypocretin precursor; Hypocretin; Hypocretin2; Hypocretin-2; Orexin B; Orexin neuropeptide precursor; Orexin precursor; Orexin; OrexinB; PPORX; PPOX

Molecular Weight

Mass (kDA):
13.363 kDA

Genomic Context


Human

Location:	17q21.2
Sequence:	17; NC_000017.11 (42184060..42185452, complement)

Tissue Specificity

Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.

Diseases

Narcolepsy
Sleep Disorders
Cataplexy
Depressive Disorder
Malignant Neoplasms
Neoplasms
Obesity
Stress, Psychological
Excessive Daytime Somnolence
Cataplexy And Narcolepsy
Substance-related Disorders
Carcinoma

Anxiety Disorders
Physiological Stress
Neurodegenerative Disorders
Nervousness
Major Depressive Disorder
Addictive Behavior
Sleeplessness

Pathways

Localization
Energy Homeostasis
Feeding Behavior
Response To Stress
Innervation
Cognition
Locomotion
Circadian Rhythm
Synaptic Transmission
Secretion
Transport
Hibernation
Cell Activation

Eating Behavior
Copulation
Membrane Depolarization
Translation
Mating
Regulation Of Feeding Behavior
Hormone Secretion

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HCRT

References

PMID: 9491897 by Sakurai T., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

PMID: 10364220 by Sakurai T., et al. Structure and function of human prepro-orexin gene.