HCLS1 Antibodies

AND HCLS1 ELISA kits, HCLS1 Proteins

Many biological assays use antibodies to detect HCLS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HCLS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HCLS1 antibodies...

We validate the specificity of these antibodies to HCLS1 by testing them on tissues known to express HCLS1 positively and negatively. Browse below to find the HCLS1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HCLS1 Infographic by Boster Bio

All HCLS1 Products

Product

Figures

Specificity

Applications

Price

Anti-HCLS1 Antibody

Human, Mouse

IHC, WB

$405
Cat # A04313
100ul

Anti-Phospho-Lck BP-1 (Y378) HCLS1 Antibody

Human

ELISA, WB

$380
Cat # A04313Y378
100ul

Anti-Phospho-Lck BP-1 (Y397) HCLS1 Antibody

Human

ELISA, WB

$380
Cat # A04313Y397
100ul

Anti-HCLS1 Antibody Picoband™

Human

ELISA, Flow Cytometry, WB

$370
Cat # A04313-1
100 μg/vial

HCLS1 (NM_005335) Human Over-expression Lysate

Human

$628
Cat # LS003059
100 µg

HCLS1 Overview

Facts about Hematopoietic lineage cell-specific protein.

HCLS1 3D structure. Source: alphafold

Hematopoietic lineage cell-specific protein (HCLS1)

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells.

May also be involved in the regulation of gene expression. .

Gene Information

Human
Gene Name:	HCLS1
Uniprot:	P14317
Entrez:	3059

Family

Belongs to:

No superfamily

Alternative Names

Cortactin-like; CTTNL; HCLS1; hematopoietic cell-specific Lyn substrate 1hematopoietic lineage cell-specific protein; HS1lckBP1; LckBP1; p75

Molecular Weight

Mass (kDA):
54.014 kDA

Genomic Context


Human

Location:	3q13.33
Sequence:	3; NC_000003.12 (121631399..121660903, complement)

Tissue Specificity

Expressed only in tissues and cells of hematopoietic origin.

Subcellular Localizations

Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.

Diseases

Leukemia
Neoplasms
Lymphoma
Chronic Lymphocytic Leukemia
Lymphoid Leukemia
Malignant Paraganglionic Neoplasm
B-cell Lymphomas
Tissue Adhesions
Immunologic Deficiency Syndromes
Leukemia, Myelocytic, Acute
Malignant Neoplasms
Myeloid Leukemia

Lupus Erythematosus, Systemic
Autoimmune Diseases
Autoimmune Reaction
Inflammation
Wiskott-aldrich Syndrome
Lymphocytic Neoplasm
Leukemia L5178

Interacting Proteins

SH2D4A
TERF1
WIPF1

Pathways

Cell Activation
Cell Migration
T Cell Activation
Cell Cycle
Cell Death
Lymphocyte Activation
Immune Response
Cell Adhesion
Chemotaxis
Cell Proliferation
Pathogenesis
Protein Phosphorylation
Platelet Activation

Regulation Of Gene Expression
Cell Cycle Arrest
Phagocytosis
Cell Differentiation
Histone Acetylation
Cytolysis
Induction Of Apoptosis

PTMs

Phosphorylation
Cleavage

Dephosphorylation
Acetylation

Acylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HCLS1

References

PMID: 2587259 by Kitamura D., et al. Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.

PMID: 7682714 by Yamanashi Y., et al. Identification of HS1 protein as a major substrate of protein- tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.