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- Table of Contents
Facts about Tyrosine-protein kinase HCK.
During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to lead to the respiratory burst. Plays a role in the release of inflammatory molecules.
Human | |
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Gene Name: | HCK |
Uniprot: | P08631 |
Entrez: | 3055 |
Belongs to: |
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protein kinase superfamily |
Bmk; EC 2.7.10; EC 2.7.10.2; Hck; Hctk; hemopoietic cell kinaseJTK9; JTK9; p59-HCK/p60-HCK; tyrosine-protein kinase HCK
Mass (kDA):
59.6 kDA
Human | |
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Location: | 20q11.21 |
Sequence: | 20; NC_000020.11 (32052242..32101843) |
Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil.
[Isoform 1]: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane; Lipid-anchor. Cytoplasm, cytosol. Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.; [Isoform 2]: Cell membrane; Lipid-anchor. Membrane, caveola; Lipid-anchor. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasmic vesicle. Lysosome. Nucleus. 20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation
PMID: 3496523 by Quintrell N., et al. Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.
PMID: 3453117 by Ziegler S.F., et al. Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.