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- Table of Contents
Facts about Histone acetyltransferase type B catalytic subunit.
May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.
Human | |
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Gene Name: | HAT1 |
Uniprot: | O14929 |
Entrez: | 8520 |
Belongs to: |
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HAT1 family |
EC 2.3.1.48; histone acetyltransferase 1; histone acetyltransferase type B catalytic subunit; KAT1
Mass (kDA):
49.513 kDA
Human | |
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Location: | 2q31.1 |
Sequence: | 2; NC_000002.12 (171922425..171983686) |
[Isoform A]: Nucleus matrix.; [Isoform B]: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
PMID: 9427644 by Verreault A., et al. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.
PMID: 11585814 by Makowski A.M., et al. Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase.