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- Table of Contents
Facts about Intracellular hyaluronan-binding protein 4.
Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114).
Human | |
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Gene Name: | HABP4 |
Uniprot: | Q5JVS0 |
Entrez: | 22927 |
Belongs to: |
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No superfamily |
chromodomain helicase DNA binding protein 3 interacting protein; hyaluronan binding protein 4; IHABP-4; IHABP4MGC825; intracellular antigen detected by monoclonal Ki-1; intracellular hyaluronan-binding protein 4; Ki-1/57 intracellular antigen; Ki-1/57; SERBP1L
Mass (kDA):
45.785 kDA
Human | |
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Location: | 9q22.32 |
Sequence: | 9; NC_000009.12 (96450162..96491336) |
Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.
Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, sarcoplasm. Nucleus, nuclear body. Nucleus, nucleolus. Nucleus speckle. Nucleus, Cajal body. Nucleus, gem. Transported into the nuclear compartment in activated leukocytes (PubMed:9523163). Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments (PubMed:16879614, PubMed:19523114). Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems) (PubMed:19523114). Colocalizes with FMR1, FXR1 and FXR2 in
PMID: 10887182 by Huang L., et al. Molecular characterization of a novel intracellular hyaluronan- binding protein.
PMID: 9523163 by Kobarg J., et al. Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen.