Histone H2AX Antibodies

AND H2AX ELISA kits, Histone H2AX Proteins

Many biological assays use antibodies to detect Histone H2AX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Histone H2AX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Histone H2AX antibodies...

We validate the specificity of these antibodies to Histone H2AX by testing them on tissues known to express H2AX positively and negatively. Browse below to find the H2AX antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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H2AX Infographic by Boster Bio

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Histone H2A.X (H2AFX) (NM_002105) Human Over-expression Lysate

Human

$628
Cat # LS003014
100 µg

H2AX Overview

Facts about Histone H2AX.

H2AX 3D structure. Source: alphafold

Histone H2AX (H2AX)

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.

Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated by means of a complex set of post-translational modifications of histones, also known as histone code, and nucleosome remodeling.

Gene Information

Human
Gene Name:	H2AX
Uniprot:	P16104
Entrez:	3014

Family

Belongs to:

histone H2A family

Alternative Names

H2A histone family, member X; H2A.X; H2a/x; H2AX histone; H2AXhistone H2A.x; YH2AX

Molecular Weight

Mass (kDA):
15.145 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (119093874..119095465, complement)

Subcellular Localizations

Nucleus. Chromosome.

Diseases

Malignant Neoplasms
Neoplasms
Ataxia Telangiectasia
Ataxia
Telangiectasis
Carcinoma
Genomic Instability
Malignant Neoplasm Of Breast
Mammary Neoplasms
Cell Transformation, Neoplastic
Lung Neoplasms
Cytogenetic Abnormality

Malignant Paraganglionic Neoplasm
Leukemia
Malignant Neoplasm Of Lung
Carcinogenesis
Radiation Induced Dna Damage
Genotoxic Stress
Adenocarcinoma

Interacting Proteins

Aifm1
BRCA1
HIST1H2BD
HIST1H4A
HIST3H3

LMNA
MAPK8
MDC1
MRE11
NBN

PPM1D
SMARCA4
TERF2
TP53BP1
VRK1

Pathways

Cell Cycle
Dna Repair
Cell Death
Dna Replication
Cell Cycle Arrest
Senescence
S Phase
Mitosis
Localization
Double-strand Break Repair
Induction Of Apoptosis
Cell Killing
Cell Proliferation

Dna Damage Checkpoint
Cell Cycle Checkpoint
Cellular Senescence
Cell Growth
Hypersensitivity
Aging
Rna Interference

PTMs

Phosphorylation
Cleavage
Dephosphorylation
Acetylation
Methylation
Ubiquitination
Reduction
Deamination

Ribosylation
Deacetylation
Demethylation
Sumoylation
Carboxylation
Iodination
Nitration
Oxidation

Research Areas

Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Mitotic Regulators
Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/H2AX

References

PMID: 2587254 by Mannironi C., et al. H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals.

PMID: 9488723 by Rogakou E.P., et al. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.