Gelsolin Antibodies

Gelsolin (GSN)

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed.

Plays a role in ciliogenesis. .

Gene Information

Human
Gene Name:	GSN
Uniprot:	P06396
Entrez:	2934

Family

Belongs to:
villin/gelsolin family

Alternative Names

Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; gelsolin (amyloidosis, Finnish type); Gelsolin; GSN

Molecular Weight

Mass (kDA):
85.698 kDA

Genomic Context

Human
Location:	9q33.2
Sequence:	9; NC_000009.12 (121201483..121332844)

Tissue Specificity

Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.

Subcellular Localizations

[Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted.

Diseases

• Neoplasms
• Malignant Neoplasms
• Pain
• Amyloidosis
• Dystrophy
• Amyloidosis, Familial
• Carcinoma
• Hereditary Corneal Dystrophy
• Carcinoma, Transitional Cell
• Visceral Pain
• Bladder Neoplasm

• Malignant Neoplasm Of Urinary Bladder
• Basal Cell Nevus Syndrome
• Tissue Adhesions
• Corneal Diseases
• Mutation Abnormality
• Hypoglycemia

Interacting Proteins

• AR
• ARRB1
• ARRB2

Pathways

• Pathogenesis
• Localization
• Cell Death
• Transport
• Cell Cycle
• Cell Adhesion
• Cell Activation
• T Cell Activation
• Aging
• Neurogenesis
• Cardiac Conduction
• Inflammatory Response
• Flight

• Reverse Transcription
• Phagocytosis
• Translation
• Axon Guidance
• Acute-phase Response
• Cell Differentiation
• Oxygen Transport

PTMs

• Phosphorylation

• Cleavage

Research Areas

• Apoptosis
• Cancer
• Cell Biology
• Cellular Markers
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GSN

Best Uses Of The GSN Marker Antibody From Boster Bio

The anti-Proteasome 20S alpha 2/PSMA2 and Anti-Glycophorin A antibodies from Boster Bio have been the subject of many studies, but which is the best one to use for your research? Here are some tips to help you decide. Also, the Boster Bio optimization guide can help you make informed decisions to improve your experiments and maximize the value of your data. While you may not run experiments with these antibodies all the time, you should be aware that each experiment will have some troubleshooting and optimization issues. The troubleshooting guides can point out common sources of error and give you suggestions to eliminate them.

Boster Bio's Anti-Glycophorin A

This boster bio antibody recognizes glycophorin A (GPA), a single-pass membrane sialoglycoprotein that carries the specificities of blood groups M, N, S, and U. This protein provides a mucin-like surface to reduce cell fusion and minimize aggregation of red blood cells in the circulation. The antibody has been used in diagnostics and characterization of erythroid cell development and disease.

Boster scientists can submit their results for species, applications, and special samples to obtain product credits. This product is available in the market for researchers around the world. It is compatible with many other anti-Glycophorin A antibodies. In addition, it is able to inhibit the hemagglutination process more effectively than glycophorin A or fetuin.

Previously, HGP44B and GPA were immunoprecipitated from erythrocyte membrane lysates. Western blot analysis using boster bio's anti-HGP44B revealed that HGP44B associates with glycophorin A and B. Both glycophorins are a major band that can be detected on SDS-PAGE gels.

Boster Bio's Anti-Proteasome 20S alpha 2/PSMA2

This antibody reacts with protein substrates on the surface of the proteasome. This enzyme is highly conformationally flexible and has multiple catalytic sites. Immunoproteasomes are found in human cells and those exposed to inflammatory cytokines. It has three catalytic activities, LMP7, LMP8, and LMP9. LMP7 is more efficient at processing antigens.

Proteasomes are multicatalytic enzymes that process most intracellular proteins. They are found in high concentrations within eukaryotic cells and are composed of four stacked rings and seven distinct subunits. The outer rings contain the catalytic sites, while the beta rings are responsible for their assembly. Proteasomes are found in animals, plants, and humans, and contain at least ten different beta-proteasome genes.

The RIP1-RIP3 complex is a critical regulator of acetaminophen-induced liver necrosis. It is also an early mediator of TNF-induced liver necrosis. The researchers of this complex have discovered that RIP3 regulates programmed necrosis and virus-induced inflammation. The research team also has several other promising discoveries.

Boster Bio's GSN Marker

Boster Bio's GSN Marker is a high-affinity antibody designed for Western Blotting, ELISA, and immunohistochemistry experiments. The antibodies are validated for Human, Mouse, and Rat. In addition to these primary antibodies, Boster also provides secondary antibodies and optimized protocols. A Boster Bio GSN Marker is the perfect choice for researchers looking to use this technology to study DNA cross-linking and other aspects of cell biology.