This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Growth factor receptor-bound protein 10.
The inhibitory effect can be achieved by two mechanisms: interference with the signaling pathway and enhanced receptor degradation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin- stimulated IRS1 and IRS2 tyrosine phosphorylation.
Human | |
---|---|
Gene Name: | GRB10 |
Uniprot: | Q13322 |
Entrez: | 2887 |
Belongs to: |
---|
GRB7/10/14 family |
GRB10 adapter protein; GRB10 adaptor protein; Grb-10; GRBIR; GRB-IR; growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; maternally expressed gene 1; MEG1; RSS
Mass (kDA):
67.231 kDA
Human | |
---|---|
Location: | 7p12.1 |
Sequence: | 7; NC_000007.14 (50590068..50793453, complement) |
Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.
Cytoplasm. When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity).
If you're looking for a high-affinity , primary antibody for the GRB10 marker, Boster is the brand for you. Their GRB10 antibodies are developed to be used in a variety of biological processes and are available in different sizes. This article will provide information on how to utilize GRB10 antibody to identify an area of interest within the human body. Learn more here. This antibody has been found to be an epitope in human the cytochrome B9.
For researchers, Boster Bio offers high-affinity primary antibodies. The company's antibodies are highly cited and have been extensively validated in immunohistochemistry, Western blotting, and ELISA methods. The antibodies are reliable in a variety of research applications. Bosterbio.com has more information on the company's products. Boster has developed these antibodies in-house unlike other companies who sell them to customers.
Boster Bio offers a wide range of high-affinity antibodies, whether you need an antigen-specific Antigen to test for an antibody or a protein. These high-affinity antibody are manufactured by a renowned company that is ISO 9001 certified. The company is specialized in the production of primary antibodies with high affinity, and is dedicated to customer satisfaction. They also offer custom-made services as well as BeNeLux delivery.
While selecting an antibody for your research, be sure to consider the specificity of the antibody. Antibodies should only have one predicted molecular mass. If there are multiple bands however, the antibodies may not be specific enough to detect the protein that is targeted. In such instances it is crucial to test antibodies using different methods. It is essential to assess the affinities of various samples in order to determine differences in antibody specificity. Check if the antibodies have sufficient signal to detect the target proteins when analyzing their affinities.
The affinity maturation limits were determined at physiological temperature with a representative set of 50 Abs from the two previous vaccinations. The results were arranged around well-defined means. The temperature change did not alter the geometric mean of koff or kon. However, koff increased 2.4-fold and this is equivalent to a drop of average interaction t1/2. This is a significant improvement over previous results.
PMID: 7479769 by Liu F., et al. Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.
PMID: 8798417 by O'Neill T.J., et al. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.