GP2 Antibodies

Pancreatic secretory granule membrane major glycoprotein GP2 (GP2)

Gene Information

Human
Gene Name:	GP2
Uniprot:	P55259
Entrez:	2813

Family

Belongs to:
No superfamily

Alternative Names

DKFZp779K0533; glycoprotein 2 (zymogen granule membrane); GP2; pancreatic secretory granule membrane major glycoprotein GP2; pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75

Molecular Weight

Mass (kDA):
59.48 kDA

Genomic Context

Human
Location:	16p12.3
Sequence:	16; NC_000016.10 (20309574..20327513, complement)

Tissue Specificity

Pancreatic secretory (zymogen) granule.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Secreted after cleavage in the pancreatic juice.

Diseases

• Malignant Neoplasms
• Hemorrhagic Fevers, Viral
• Lymphocytic Choriomeningitis
• Neoplasms
• Malignant Neoplasm Of Breast
• Virus Diseases
• Porcine Reproductive And Respiratory Syndrome
• Mammary Neoplasms
• Hemorrhagic Fever, Ebola
• Lassa Fever
• Pancreatitis
• Crohn Disease
• Pancreatic Neoplasm

• Influenza
• Infective Disorder
• Carcinoma
• Ulcerative Colitis
• Ulcer
• Neoplasm Metastasis
• Stomatitis

Pathways

• Secretion
• Membrane Fusion
• Glycosylation
• Pathogenesis
• Endocytosis
• Exocytosis
• Immune Response
• Transport
• Proteolysis
• Localization
• Secretory Pathway
• Transcytosis
• Tropism

• Cell Differentiation
• Regeneration
• Protein Secretion
• Virulence
• Translation
• Rna Interference
• Fermentation

PTMs

• Cleavage
• Glycosylation
• Phosphorylation
• Gpi Anchoring
• Myristoylation
• Biotinylation

• Methylation
• Reduction
• Hydroxylation
• Acetylation
• Ribosylation
• Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GP2

Best Uses of the GP2 Marker in Boster Bio

This article will cover the Best uses of the GP2 Marker in Boster Bio. The article also provides a troubleshooting guide. You will be taught how to optimize the Boster Bio system. This article will go over the GP2 binding process to bacteria and the steps needed to optimize it. Once you've mastered optimization It's time to know more about the GP2 binding process.

Tips for optimizing your performance

If you're looking for more information on GP2 or other markers, you can look up the Boster Bio gene infographics. They provide basic information about every gene that is found in the mouse and human genomes. Boster also has a gene search tool that can help you locate the gene you are seeking. Boster Bio also has information about flow techniques.

GP2 binding to bacteria

In vitro diagnostics for pathogenic bacteria are based on the detection of GP2 markers. These molecules are able to decrease complement activation on the microbial surfaces. This is essential for the survival and development of vaccines. These molecules can now be identified by using new techniques. This review will discuss recent developments in understanding the mechanisms that bind these proteins play with microbial surface proteins. We also discuss recent findings regarding the common motives for these proteins, which favor microbial attachment. We also review the importance and quantity of complement evasion proteins, which play a crucial function in the survival of bacterial species.

Repair of the chromosomes

In pancreatic cancer rs78193826, an inherited variant of GP2, modulates the activity of the oncogenic gene KRAS. The GP2 variant may interact with KRAS and other possible effector genes. We therefore looked into whether this mutation plays a role in the development of pancreatic cancer. This study supports the hypothesis that rs78193826 may be involved in pancreatic cancer.

Many phenotypes are linked to the GP2 gene. It has been associated with pancreatic cancer and is closely related to a family history of the disease. There is no study established a causal link between rs11726780808 and pancreatic carcinoma. Genetic variations in the GP2 gene are associated with various illnesses that include pancreatic cancer diabetes, and other forms of pancreatic cancer.

We used a ranked list metric, GFOLD, to determine the number of genes significantly differentially expressed. The GFOLD metric shows gene expression in a set of four cells. Expression levels of genes were converted to log2(RPKM) values, and the average value was subtracted from the expression levels in all four cells. The heatmap identifies genes whose expression is greater or lower than that of the GP2_WT cells.

AmE1102 (the shortest known gp2 protein).

The highly efficient RNA polymerase inhibitor AmE1102 from Boster Bio lab blocks H-T joining and is the shortest lprophage-encoded Gp2 protein. The peptides synthesized by it were created from human L-prophages. AmE1102 was derived from bacteria that were altered since the late 1970s. AmE1102 is a product of Boster Bio and is currently available for research use.

The r-prophages produced by reconstitution of AmE1102 comprise only two exons. So, r-gp2 doesn't increase the yield of phage. Furthermore, the shortest gp2 protein from Boster Bio is not effective in phage reconstitution due to the fact that it interferes with H-T joining.

Centricon microconcentrator 10 was used to purify the r-gp2 protein. After that, the peptide was rinsed in water to get rid of glycerol and Tris. Automated Edman degrading was employed to determine the gp2 gp2 sequence. In a recent study AmE1102 was found to be more effective than r-gp2 in protecting DNA.

Purified gp2 was shown to increase the number phages that are present in an H.T. joining as opposed to T-T extract. In vitro, wild-type Gp2 is ineffective in giving 2+ phenotypes to H-T heads. However, rgp2 has an advantage in this in this regard.