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GNB5 Antibodies
AND GNB5 ELISA kits, GNB5 Proteins
Many biological assays use antibodies to detect GNB5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNB5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNB5 antibodies...
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GNB5 Overview
Facts about Guanine nucleotide-binding protein subunit beta-5.
Guanine nucleotide-binding protein subunit beta-5 (GNB5)
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260).
May play an important role in neuronal signaling, including in the mind, but not sympathetic, control of heart rate (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | GNB5 |
| Uniprot: | O14775 |
| Entrez: | 10681 |
Family
| Belongs to: |
|---|
| WD repeat G protein beta family |
Alternative Names
FLJ37457; FLJ43714; G protein, beta subunit 5L; G protein, beta-5 subunit; GB5; gbeta5; guanine nucleotide binding protein (G protein), beta 5; guanine nucleotide-binding protein subunit beta-5; guanine nucleotide-binding protein, beta subunit 5L; Transducin beta chain 5
Molecular Weight
Mass (kDA):
43.566 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.2 |
| Sequence: | 15; NC_000015.10 (52115100..52191392, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Membrane.
Diseases
- Nervousness
- Pheochromocytoma
- Pertussis
- Pituitary Diseases
- Obesity
- Cholangiocarcinoma
- Reperfusion Injury
- Malnutrition
- Spinal Cord Injuries
- Infarction
- Myelitis
- Coinfection
Pathways
- Localization
- Phototransduction
- Brain Development
- Proteolysis
- Sensitization
- Transport
- Intracellular Transport
- Synaptic Transmission
- Cell Cycle Arrest
- Lipid Modification
- Reverse Transcription
- Cell Cycle
PTMs
- Palmitoylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNB5
bosterbio.com/bosterbio-gene-info-cards/GNB5
References
PMID: 9606987 by Jones P.G., et al. Cloning and tissue distribution of the human G protein beta 5 cDNA.
PMID: 10521509 by Posner B.A., et al. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.