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GDF15 Antibodies
AND GDF15 ELISA kits, GDF15 Proteins
Many biological assays use antibodies to detect GDF15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GDF15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GDF15 antibodies...
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GDF15 Infographic by Boster Bio
All GDF15 Products
Product
Figures
Specificity
Applications
Price
Rat GDF-15 ELISA Kit PicoKine®
1 Citations 11 Q&As
Rat
ELISA
$499
Cat # EK1561
96 wells/kit, with removable strips.
Cat # EK1561
96 wells/kit, with removable strips.
Human GDF-15 ELISA Kit PicoKine®
2 Citations 10 Q&As
Human
ELISA
$499
Cat # EK0767
96 wells/kit, with removable strips.
Cat # EK0767
96 wells/kit, with removable strips.
Mouse GDF-15 ELISA Kit PicoKine®
12 Q&As
Mouse
ELISA
$499
Cat # EK1134
96 wells/kit, with removable strips.
Cat # EK1134
96 wells/kit, with removable strips.
Anti-Nag-1 GDF15 Antibody Peroxidase Conjugated
1 Citations 16 Q&As
Human, Mouse
ELISA
$591
Cat # A01583-3
100ug
Cat # A01583-3
100ug
Human
ELISA
$500
Cat # EZ0767
For 5 plates, 96 wells each
Cat # EZ0767
For 5 plates, 96 wells each
Human
ELISA
$499
Cat # FEK0767
96 wells/kit, with removable strips.
Cat # FEK0767
96 wells/kit, with removable strips.
GDF15 Overview
Facts about Growth/differentiation factor 15.
Growth/differentiation factor 15 (GDF15)
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, also activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).
It then triggers the activation of neurons localized inside the parabrachial nucleus and central amygdala, which contitutes part of the'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | GDF15 |
| Uniprot: | Q99988 |
| Entrez: | 9518 |
Family
| Belongs to: |
|---|
| TGF-beta family |
Alternative Names
GDF15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; MIC-1NSAID-activated gene 1 protein; MIC1Prostate differentiation factor; NAG-1; NAG-1NSAID-regulated gene 1 protein; NSAID (nonsteroidal inflammatory drug)-activated protein 1; PDF; PDFGDF-15; PLAB; PLABNRG-1; Placental bone morphogenetic protein; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta
Molecular Weight
Mass (kDA):
34.14 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.11 |
| Sequence: | 19; NC_000019.10 (18382170..18389176) |
Tissue Specificity
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093). Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435).
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Inflammation
- Cell Transformation, Neoplastic
- Colorectal Cancer
- Malignant Tumor Of Colon
- Colorectal Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
Interacting Proteins
- MDFI
Pathways
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Secretion
- Cell Death
- Cell Cycle Arrest
- Induction Of Apoptosis
- Pathogenesis
- Methylation
- Angiogenesis
- Macrophage Activation
- Wound Healing
- Localization
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Demethylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GDF15
bosterbio.com/bosterbio-gene-info-cards/GDF15
References
PMID: 9375789 by Hromas R., et al. PLAB, a novel placental bone morphogenetic protein.
PMID: 9348093 by Yokoyama-Kobayashi M., et al. Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta.
4 Publications of Boster GDF15 Antibodies & ELISA Kits
- PubMed ID: 10.1152/ajpendo.90672.2008, Diabetes-induced upregulation of urotensin II and its receptor plays an importan...
- PubMed ID: 10.1080/10641955.2018.1524477, Maternal levels of growth differentiation factor-15 in patients with preeclampsi...
- PubMed ID: 30295110 , Maternal levels of growth differentiation factor-15 in patients with preeclampsi...
- PubMed ID: 22117761, Wang Y, Li D, Xu N, Tao W, Zhu R, Sun R, Fan W, Zhang P, Dong T, Yu L. Arthritis...
*More publications can be found for each product on its corresponding product page