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GADD45GIP1 Antibodies
AND GADD45GIP1 ELISA kits, GADD45GIP1 Proteins
Many biological assays use antibodies to detect GADD45GIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GADD45GIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GADD45GIP1 antibodies...
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GADD45GIP1 Overview
Facts about Growth arrest and DNA damage-inducible proteins-interacting protein 1.
Growth arrest and DNA damage-inducible proteins-interacting protein 1 (GADD45GIP1)
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins.
Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | GADD45GIP1 |
| Uniprot: | Q8TAE8 |
| Entrez: | 90480 |
Family
| Belongs to: |
|---|
| mitochondrion-specific ribosomal protein mL64 family |
Alternative Names
CKBBP2; CKII beta-associating protein; CR6 interacting factor 1; CRIF1p53-responsive gene 6 protein; growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible, gamma interacting protein 1; MGC4667; MGC4758; papillomavirus L2 interacting nuclear protein 1; Papillomavirus L2-interacting nuclear protein 1; Plinp1; PLINP-1CKII beta binding protein 2; PRG6CR6-interacting factor 1
Molecular Weight
Mass (kDA):
25.384 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.13 |
| Sequence: | 19; NC_000019.10 (12953119..12957223, complement) |
Tissue Specificity
Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
Subcellular Localizations
Mitochondrion. Nucleus. Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).
Diseases
- Malignant Neoplasms
- Carcinoma
- Neoplasms
- Growth Arrest
- Malignant Neoplasm Of Prostate
- Adenocarcinoma
- Pancreatic Ductal Adenocarcinoma
- Adenoma
- Tumor Progression
- Ovarian Serous Adenocarcinoma
- Retinoblastoma
- Adrenal Cortical Adenoma
Interacting Proteins
- GADD45A
- Gadd45b
- GADD45G
- STAT3
- Stat3
Pathways
- Cell Cycle
- Cell Growth
- Negative Regulation Of Growth
- Drug Resistance
- Regulation Of Cell Cycle
- Cell Proliferation
- Translation
- Regulation Of Growth
- S Phase
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GADD45GIP1
bosterbio.com/bosterbio-gene-info-cards/GADD45GIP1
References
PMID: 12482659 by Goernemann J., et al. Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins.
PMID: 12716909 by Chung H.K., et al. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.