GSTT1 Antibodies

Glutathione S-transferase theta-1 (GSTT1)

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide.

Displays glutathione peroxidase activity with cumene hydroperoxide. .

Gene Information

Human
Gene Name:	GSTT1
Uniprot:	P30711
Entrez:	2952

Family

Belongs to:
GST superfamily

Alternative Names

EC 2.5.1.18; glutathione S-transferase theta 1; glutathione S-transferase theta-1; Glutathione transferase T1-1; GST class-theta-1

Molecular Weight

Mass (kDA):
27.335 kDA

Genomic Context

Human
Location:	22q11.23
Sequence:	22; NT_187633.1 (270308..278486, complement)

Tissue Specificity

Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Malignant Squamous Cell Neoplasm
• Malignant Neoplasm Of Lung
• Lung Neoplasms
• Carcinogenesis
• Malignant Neoplasm Of Breast
• Leukemia
• Mammary Neoplasms
• Malignant Neoplasm Of Urinary Bladder
• Bladder Neoplasm
• Colorectal Cancer

• Colorectal Neoplasms
• Adenocarcinoma
• Cytogenetic Abnormality
• 5,10-methylenetetrahydrofolate Reductase Deficiency
• Malignant Neoplasm Of Prostate
• Stomach Neoplasms
• Myeloid Leukemia

Interacting Proteins

• ACTN2

Pathways

• Dna Repair
• Pathogenesis
• Conjugation
• Excretion
• Methylation
• Aging
• Transport
• Immune Response
• Localization
• Cell Proliferation
• Mismatch Repair
• Inflammatory Response
• Cell Cycle

• Dna Methylation
• Metaphase
• Cytokinesis
• Response To Oxidative Stress
• Hypersensitivity
• Cell Death
• Fermentation

PTMs

• Acetylation
• Methylation
• Oxidation
• Reduction

• Hydroxylation
• Phosphorylation
• Glutathionylation
• Cleavage

Research Areas

• Asthma
• Cancer
• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GSTT1

Best Uses Of The GSTT1 Marker

Are you interested in knowing more about Steven Boster This article will provide more details. You'll learn about His background, work and professional life as well as his interests. You'll be surprised by the amount of work He's accomplished! Find out some interesting details about Boster's life and his interests. You might also be interested in learning more about his favorite subjects. Here is a brief biography of Boster.

The story of Steven Boster's past

Steve Boster's life was quite interesting. He was born in Joliet, Illinois on June 6 the 6th of June, 1920. He worked for a number of years in retail sales before becoming a U.S. Army Veteran. Steve was a Concordia Hall member in Staunton, Virginia. He also was honored to be the father of Donald, Sr. and David Boster. His children and family survive him, including his daughters Natosha Peck and Crystal Boster, and his sister Tammy. Steven Boster leaves behind his wife, Sandra Blanton and Lisa Milton. Jonathan, his son Jonathan and his grandson Cory reside in Herrin, Illinois.

Steve's love of southern gospel music has fuelled his lifelong love for playing guitar and singing. He was particularly proud of his children, whom he loved more than anything. He loved sports, especially teams that were in competition. Auto racing was another love for Steve. He was never late on a Friday night at the local track. Even in subzero temperatures, Steven Boster would show up to assist. In the same way, Steven Boster's generosity extended to his family and friends. He treated them as if they were family.

His work

His work with the GSTT1 marker has highlighted several implications of the condition. GSTs are responsible for detoxifying electrophilic compounds as well as controlling the induction of proteins. In the absence of GSTT1 could lead to more damage to the genotoxic system. Taxol, ethylene oxide, and 1,3-butadiene all impact cellular metabolism and are often associated with cancer.

The Indian ethnic population is diverse both culturally as well physiologically. Many people from northern India belong to different Indo-European tribes of ancestry. To test this theory, Dr. Joshi looked at the GSTM1 and GSTT1 genotype distribution in Himmachal Pradesh, a region of northern India. The results were then compared with those of other Indian states as well as global populations.

His career

The GSTT1 gene could be used as a DNA biomarker to test donors prior to being isolated from bone marrow. Ex vivo expansion of hMSCs could reduce manufacturing times and costs. The potential application of GSTT1 in hMSCs for therapeutic reasons could be enhanced if it is validated as a PCa biomarker.