Gasdermin-E Antibodies

AND GSDME ELISA kits, Gasdermin-E Proteins

Many biological assays use antibodies to detect Gasdermin-E, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gasdermin-E in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gasdermin-E antibodies...

We validate the specificity of these antibodies to Gasdermin-E by testing them on tissues known to express GSDME positively and negatively. Browse below to find the GSDME antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GSDME Infographic by Boster Bio

All GSDME Products

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Product

Figures

Specificity

Applications

Price

Anti-DFNA5 GSDME Antibody

Human, Mouse, Rat

$405
Cat # A32407
100ul

Anti-DFNA5 GSDME Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A32407-1
100ul

GSDME (NM_004403) Human Over-expression Lysate

Human

$628
Cat # LS001687
100 µg

GSDME Overview

Facts about Gasdermin-E.

GSDME 3D structure. Source: alphafold

Gasdermin-E (GSDME)

Plays a role in the TP53-regulated cellular response to DNA damage likely by cooperating with TP53 (PubMed:16897187, PubMed:18223688). .

Gene Information

Human
Gene Name:	GSDME
Uniprot:	O60443
Entrez:	1687

Family

Belongs to:

gasdermin family

Alternative Names

Gasdermin-E

Molecular Weight

Mass (kDA):
54.555 kDA

Genomic Context


Human

Location:	7p15.3
Sequence:	7; NC_000007.14 (24698355..24762235, complement)

Tissue Specificity

Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.

Subcellular Localizations

[Gasdermin-E, N-terminal]: Cell membrane.; [Gasdermin-E]: Cytoplasm, cytosol.

Diseases

Deafness, autosomal dominant, 5 (DFNA5)

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GSDME

References

PMID: 9771715 by Van Laer L., et al. Nonsyndromic hearing impairment is associated with a mutation in DFNA5.

PMID: 9523727 by Thompson D.A., et al. Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas.