Gasdermin-A Antibodies

AND Gsdma ELISA kits, Gasdermin-A Proteins

Many biological assays use antibodies to detect Gasdermin-A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gasdermin-A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gasdermin-A antibodies...

We validate the specificity of these antibodies to Gasdermin-A by testing them on tissues known to express Gsdma positively and negatively. Browse below to find the Gsdma antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Gsdma Infographic by Boster Bio

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GSDMA (NM_178171) Human Over-expression Lysate

Human

$960
Cat # LS284110
100 µg

Gsdma Overview

Facts about Gasdermin-A.

Gasdermin-A (Gsdma)

May promote pyroptosis. Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, like possibly phosphatidylinositol (4,5)-bisphosphate.

Homooligomerizes inside the membrane and creates pores of 10 -15 nanometers (nm) of internal diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity.

Gene Information

Mouse
Gene Name:	Gsdma
Uniprot:	Q9EST1
Entrez:	57911

Family

Belongs to:

gasdermin family

Alternative Names

FKSG9; Gasdermin 1; Gasdermin A; Gasdermin; Gasdermin-1; GSDM; GSDM1

Molecular Weight

Mass (kDA):
49.593 kDA

Genomic Context


Mouse

Location:	11\|11 D
Sequence:	11;

Tissue Specificity

Expressed predominantly in the gastrointestinal (GI) tract and in the skin at a lower level. In the GI tract, the expression is highly restricted to the esophagus and forestomach.

Diseases

Malignant Neoplasms
Asthma
Malignant Neoplasm Of Stomach
Stomach Neoplasms
Immediate Hypersensitivity
Carcinogenesis
Cell Transformation, Neoplastic
Malignant Paraganglionic Neoplasm
Childhood Asthma
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Dermatitis, Atopic

Lung Diseases
Neoplasms
Dysequilibrium Syndrome
Esophageal Neoplasms
Dermatitis
Respiratory Hypersensitivity
Autoimmune Diseases

Pathways

Catagen
Flight
Secretion
Lymphocyte Activation

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Gsdma

References

PMID: 10967128 by Saeki N., et al. Gasdermin (Gsdm) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells.

PMID: 17350798 by Tamura M., et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.