GRWD1 Antibodies

AND GRWD1 ELISA kits, GRWD1 Proteins

Many biological assays use antibodies to detect GRWD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRWD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRWD1 antibodies...

We validate the specificity of these antibodies to GRWD1 by testing them on tissues known to express GRWD1 positively and negatively. Browse below to find the GRWD1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GRWD1 Infographic by Boster Bio

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GRWD1 (NM_031485) Human Over-expression Lysate

Human

$628
Cat # LS083743
100 µg

GRWD1 Overview

Facts about Glutamate-rich WD repeat-containing protein 1.

GRWD1 3D structure. Source: alphafold

Glutamate-rich WD repeat-containing protein 1 (GRWD1)

Histone binding-protein that modulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). .

Gene Information

Human
Gene Name:	GRWD1
Uniprot:	Q9BQ67
Entrez:	83743

Family

Belongs to:

No superfamily

Alternative Names

CDW4; CUL4- and DDB1-associated WDR protein 4; glutamate-rich WD repeat containing 1; GRWDglutamate rich WD repeat protein GRWD; KIAA1942regulator of ribosome biogenesis 1 homolog; RRB1; WD repeat domain 28; WDR28glutamate-rich WD repeat-containing protein 1

Molecular Weight

Mass (kDA):
49.419 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (48445983..48457022)

Subcellular Localizations

Nucleus, nucleolus. Nucleus. Chromosome. Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725).

Diseases

Cell Transformation, Neoplastic
Malignant Neoplasms
Neoplasms
Colorectal Neoplasms
Genomic Instability
Colorectal Cancer

Hyperplasia

Pathways

Ribosome Biogenesis
Dna Replication
Regulation Of Dna Replication
Cell Cycle
Chromosome Segregation

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRWD1

References

PMID: 17041588 by Higa L.A., et al. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

PMID: 14990995 by Yoshida K., et al. Regulation of Geminin and Cdt1 expression by E2F transcription factors.