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GRM6 Antibodies
AND GRM6 ELISA kits, GRM6 Proteins
Many biological assays use antibodies to detect GRM6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRM6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRM6 antibodies...
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GRM6 Infographic by Boster Bio
All GRM6 Products
Product
Figures
Specificity
Applications
Price
Anti-mGluR6 GRM6 Antibody
3 Q&As
Human, Mouse, Rat
ELISA, IHC-P, WB, IF (paraffin)
$335
Cat # A06163-1
100ul
Cat # A06163-1
100ul
Human
ELISA
$480
Cat # EKC1367
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1367
1 kit, containing one 96-well plate and all necessary reagents
GRM6 Overview
Facts about Metabotropic glutamate receptor 6.
Metabotropic glutamate receptor 6 (GRM6)
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Signaling inhibits adenylate cyclase activity (By similarity). Signaling arouses TRPM1 station activity and Ca(2+) uptake.
Gene Information
| Human | |
|---|---|
| Gene Name: | GRM6 |
| Uniprot: | O15303 |
| Entrez: | 2916 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 3 family |
Alternative Names
CSNB1B; glutamate receptor, metabotropic 6; Gm3; GPRC1F; GPRC1Fmetabotropic glutamate receptor 6; GRM6; mGlu6; mGluR6; MGLUR6DKFZp686H1993
Molecular Weight
Mass (kDA):
95.468 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q35.3 |
| Sequence: | 5; NC_000005.10 (178978327..178995320, complement) |
Tissue Specificity
Detected in melanocytes.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Diseases
- Night Blindness
- Blind Vision
- Congenital Stationary Night Blindness
- Myopia
- Retinal Diseases
- Genetic Diseases, X-linked
- Eye Diseases, Hereditary
- Nystagmus
- Severe Myopia
- Congenital Night Blindness
- Kidney Neoplasm
- Carcinogenesis
Pathways
- Signal Transmission
- Synaptic Transmission
- Pigmentation
- Localization
- Methylation
- Dna Hypermethylation
- Dna Hypomethylation
PTMs
Research Areas
- Amino Acids, Drugs and other small molecules
- GPCR
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
- Sensory Systems
- Signal Transduction
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRM6
bosterbio.com/bosterbio-gene-info-cards/GRM6
References
PMID: 9215706 by Hashimoto T., et al. The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6.
PMID: 23452348 by Devi S., et al. Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes.