Metabotropic glutamate receptor 5 (GRM5)

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an essential role in the regulation of synaptic plasticity and the modulation of the neural network activity.